Mouse TRIM29 Monoclonal Antibody | anti-TRIM29 antibody

TRIM29 (Lung Squamous Cell Carcinoma Marker) Mouse Monoclonal Antibody

Cat. Num. AAA62746

• Gene Names: TRIM29; ATDC
• Reactivity: Human.; Others not known
• Applications: Immunohistochemistry, Immunofluorescence, Flow Cytometry, Functional Assay
• Synonyms: TRIM29, Antibody; TRIM29 (Lung Squamous Cell Carcinoma Marker) Mouse Monoclonal Antibody; Ataxia telangiectasia group D complementing gene (ATDC); Tripartite motif-containing protein 29 (TRIM29);; anti-TRIM29 antibody

• Host: Mouse
• Reactivity: Human.; Others not known
• Clonality: Monoclonal
• Isotype: IgG2a, kappa
• Clone Number: TRIM29/1041
• Specificity: It recognizes a 66kDa protein, which is identified as Tripartite motif-containing protein 29 (TRIM29). It interacts with the intermediate filament protein vimentin, a substrate for the PKC family of protein kinases, and with hPKCI-1, an inhibitor of the PKCs. TRIM29 protein contains both zinc finger and leucine zipper motifs, suggesting that the it may form homodimers and possibly associate with DNA. High expression of TRIM29 has been reported in gastric cancer and pancreatic cancer, and correlates with enhanced tumor growth and lymph node metastasis. TRIM29 is also able to distinguish lung squamous cell carcinoma from lung adenocarcinoma with ~90% positive accuracy, when used in a panel with TTF-1, p63, CK5/6, and Napsin-A antibodies.
• Form/Format: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 1mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
• Sequence Length: 588

• Applicable Applications for anti-TRIM29 antibody: IHC (Immunohistochemistry), IF (Immunofluorescence), FCM/FACS (Flow Cytometry)
• Cellular Localization: Cytoplasmic & Cell Surface
• Immunogen: Recombinant fragment (126 Amino acid residues between aa 1-200) of human TRIM29 protein
• Hu-Chromosome Location: 11q23.3
• Positive Control: A431 cells. Tonsil or Squamous cell carcinoma.
• Preparation and Storage: Antibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

IHC (Immunohiostchemistry)

(Formalin-fixed, paraffin-embedded human Esophageal carcinoma stained with TRIM29 Monoclonal Antibody (TRIM29/1041).)

IHC (Immunohistochemistry)

(Formalin-fixed, paraffin-embedded human Lung Squamous Cell Carcinoma stained with TRIM29 Monoclonal Antibody (TRIM29/1041).)

References

Kosaka Y, et al. Tripartite motif-containing 29 (TRIM29) is a novel marker for lymph node metastasis in gastric cancer. Ann Surg Oncol. 14(9): 2543-9. 2007. Ring BZ, et al. A novel five-antibody immunohistochemical test for sub-classification of lung carcinoma. Mod Pathol. 22(8): 1032-43. 2009

NCBI and Uniprot Product Information

• NCBI GI #: 17402909
• NCBI GeneID: 23650
• NCBI Accession #: NP_036233.2
• NCBI GenBank Nucleotide #: NM_012101.3
• UniProt Accession #: Q14134; Q96AA9; Q9BZY7
• Molecular Weight: 66kDa
• NCBI Official Full Name: tripartite motif-containing protein 29
• NCBI Official Synonym Full Names: tripartite motif containing 29
• NCBI Official Symbol: TRIM29
• NCBI Official Synonym Symbols: ATDC
• NCBI Protein Information: tripartite motif-containing protein 29
• UniProt Protein Name: Tripartite motif-containing protein 29
• UniProt Gene Name: TRIM29
• UniProt Synonym Gene Names: ATDC
• UniProt Entry Name: TRI29_HUMAN