IHC (Immunohiostchemistry)
(Immunochemical staining of human TRIM29 in human skin with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)
Rabbit anti-Human TRIM29 Polyclonal Antibody | anti-TRIM29 antibody
TRIM29 Antibody, Rabbit PAb, Antigen Affinity Purified
Reactivity
Human
Applications
Immunohistochemistry
Purity
Protein A & Antigen Affinity
Synonyms
TRIM29, Antibody; TRIM29 Antibody, Rabbit PAb, Antigen Affinity Purified; Anti-TRIM29 Antibody, Rabbit Polyclonal; Anti-TRIM29 Antibody; anti-TRIM29 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
Human TRIM29
Purity/Purification
Protein A & Antigen Affinity
Form/Format
Liquid. PBS, pH7.0 with 0.03% Proclin300
Applicable Applications for anti-TRIM29 antibody
IHC (Immunohistochemistry)
Immunogen
E Coli-derived Human TRIM29 fragment
Conjugation
Unconjugated
Preparation
Produced in rabbits immunized with E Coli-derived Human TRIM29 fragment, and purified by antigen affinity chromatography.
Preparation and Storage
This antibody can be stored at 2 degree C-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Avoid repeated freeze-thaw cycles.
IHC (Immunohiostchemistry)
(Immunochemical staining of human TRIM29 in human skin with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)
IHC (Immunohiostchemistry)
(Immunochemical staining of human TRIM29 in human skin with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)
IHC (Immunohistochemistry)
(Immunochemical staining of human TRIM29 in human esophagus with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)
IHC (Immunohistochemistry)
(Immunochemical staining of human TRIM29 in human esophagus with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)
Related Product Information for anti-TRIM29 antibody
Background: TRIM29, a member of the TRIM family of proteins, functions as an inducible negative regulator of innate immune response triggered by DNA virus and cytosolic DNA. Knockdown of TRIM29 in airway epithelial cells enhances type I interferon production, and in human nasopharyngeal carcinoma cells results in almost complete Epstein-Barr virus clearance. TRIM29 is also highly induced by cytosolic double-stranded DNA in myeloid dendritic cells. Proteins of the TRIM family have regulatory functions in immune signaling, often via ubiquitination of target proteins. TRIM29 is induced upon infection with DNA viruses, resulting in degradation of STING, decreased interferon signaling and increased pathogenicity in mice. TRIM29 is a crucial negative regulator in immune response to DNA virus and cytosolic DNA, preventing potential damage caused by overcommitted immune responses.
References
Xing J, et al. (2018) Trim29 negatively regulates the type i ifn production in response to rna virus. J Immunol 201 (1): 183-192.
Xing J, et al. (2017) Trim29 promotes DNA virus infections by inhibiting innate immune response. Nat Commun 8 (1): 945.
Li Q, et al. (2018) Trim29 negatively controls antiviral immune response through targeting sting for degradation. Cell Discov 4 13.
Xing J, et al. (2017) Trim29 promotes DNA virus infections by inhibiting innate immune response. Nat Commun 8 (1): 945.
Li Q, et al. (2018) Trim29 negatively controls antiviral immune response through targeting sting for degradation. Cell Discov 4 13.
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Product Notes
The TRIM29 (Catalog #AAA258284) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TRIM29 Antibody, Rabbit PAb, Antigen Affinity Purified reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's TRIM29 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry). Researchers should empirically determine the suitability of the TRIM29 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TRIM29, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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