Mouse anti-Human LCK Antibody | anti-LCK antibody
Anti-LCK Purified
Gene Names
LCK; LSK; YT16; IMD22; p56lck; pp58lck
Reactivity
Human
Applications
Immunocytochemistry, Western Blot, Immunoprecipitation, Flow Cytometry, Functional Assay
Purity
Purified by Protein-A Affinity Chromatography
Synonyms
LCK; N/A; Anti-LCK Purified; LCK proto-oncogene, Src family tyrosine kinase; p56Lck; anti-LCK antibody
Host
Mouse
Reactivity
Human
Isotype
IgG1
Clone Number
LCK-01
Specificity
The antibody LCK-01 recognizes defined epitope (aa 22-36) of Lck, a 56 kDa Src-family protein tyrosine kinase (intracellular antigen).
Purity/Purification
Purified by Protein-A Affinity Chromatography
Form/Format
Phosphate buffered saline (PBS) solution with 15 mM sodium azide
Concentration
1 mg/ml (varies by lot)
Sequence Length
509
Applicable Applications for anti-LCK antibody
ICC (Immunocytochemistry), WB (Western Blot), IP (Immunoprecipitation), FCM/FACS (Flow Cytometry)
Immunogen
Peptide corresponding to amino acids 22-36 in the sequence of human Lck.
Negative Species
Mouse
Preparation and Storage
Store at 2-8 degree C.
Related Product Information for anti-LCK antibody
Lck is a Src-family tyrosine kinase, which is essential for signaling through the T-cell receptor (TCR) complex. Upon TCR triggering, Lck phosphorylates the ITAM motives in its zeta subunits, establishing binding sites for the SH2 domains of the tyrosine kinase ZAP70, which is also phosphorylated by Lck and thereby activated to generate subsequent signaling platforms by phosphorylation of adaptor LAT. Whereas the majority of Lck is localized to the plasma membrane, there is also a significant fraction associated with the Golgi apparatus, which may contribute to Raf activation under conditions of weak stimulation through the TCR. Lck is also involved in the regulation of apoptosis induced by various stimuli, but not by the death receptors.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
NCBI Official Full Name
tyrosine-protein kinase Lck isoform a
NCBI Official Synonym Full Names
LCK proto-oncogene, Src family tyrosine kinase
NCBI Official Symbol
LCK
NCBI Official Synonym Symbols
LSK; YT16; IMD22; p56lck; pp58lck
NCBI Protein Information
tyrosine-protein kinase Lck
UniProt Protein Name
Tyrosine-protein kinase Lck
UniProt Gene Name
LCK
UniProt Synonym Gene Names
LSK
UniProt Entry Name
LCK_HUMAN
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Product Notes
The LCK lck (Catalog #AAA128660) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Anti-LCK Purified reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's LCK can be used in a range of immunoassay formats including, but not limited to, ICC (Immunocytochemistry), WB (Western Blot), IP (Immunoprecipitation), FCM/FACS (Flow Cytometry). Researchers should empirically determine the suitability of the LCK lck for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "LCK, Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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