IHC (Immunohiostchemistry)
(Figure 2: Immunohistochemical analysis of paraffin-embedded mammary cancer tissues (left) and ovarian cancer tissues (right) using NACC1 mouse mAb with DAB staining.)
Mouse anti-Human NAC1 Antibody | anti-NAC1 antibody
NAC1 Antibody
Gene Names
NACC1; NAC1; BEND8; NAC-1; NECFM; BTBD30; BTBD14B
Reactivity
Human
Applications
ELISA, Immunohistochemistry, Western Blot
Synonyms
NAC1; N/A; NAC1 Antibody; BEND8; NAC-1; BTBD14B; FLJ37383; NACC1; anti-NAC1 antibody
Host
Mouse
Reactivity
Human
Isotype
IgG1
Clone Number
6H2
Form/Format
Ascitic fluid containing 0.03% sodium azide.
Sequence Length
527
Applicable Applications for anti-NAC1 antibody
ELISA, IHC (Immunohistochemistry), WB (Western Blot)
Immunogen
Purified recombinant fragment of human NACC1 expressed in E. Coli.
Preparation and Storage
Store at 4 degree C, for long term storage, store at-20 degree C.
IHC (Immunohiostchemistry)
(Figure 2: Immunohistochemical analysis of paraffin-embedded mammary cancer tissues (left) and ovarian cancer tissues (right) using NACC1 mouse mAb with DAB staining.)
IHC (Immunohiostchemistry)
(Figure 2: Immunohistochemical analysis of paraffin-embedded mammary cancer tissues (left) and ovarian cancer tissues (right) using NACC1 mouse mAb with DAB staining.)
WB (Western Blot)
(Figure 1: Western blot analysis using NACC1 mAb against HEK293 (1) and NACC1-hIgGFc transfected HEK293 (2) cell lysate.)
WB (Western Blot)
(Figure 1: Western blot analysis using NACC1 mAb against HEK293 (1) and NACC1-hIgGFc transfected HEK293 (2) cell lysate.)
Related Product Information for anti-NAC1 antibody
NAC1 or nuclear accumbens-1 is a nuclear factor that belongs to the POZ/BTB (Pox virus and zinc finger/bric-a-brac tramtrack broad complex) domain family. Also known as BTBD14B, it was originally identified in a unique neuronal forebrain structure responsible for reward motivation and addictive behaviors. NAC1 recruits HDAC3 and HDAC4 to transcriptionally repress gene expression in neuronal cells (3) and specifically co-represses other POZ/BTB proteins in the central nervous system. NAC1 is upregulated in several tumor types, including breast, renal cell, and hepatocellular carcinoma, as well as high grade ovarian serous carcinoma, where it has long been suspected as a chemoresistance gene. The chemoresistance mechanism reportedly occurs through NAC1 negative regulation of the GADD45 pathway. NAC1 has also been described as part of the extended transcriptional network in pluripotent cells that involves Oct-4, Sox2, Nanog, Sall1, KLF4 and Sall4.
Product Categories/Family for anti-NAC1 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
58kDa
NCBI Official Full Name
nucleus accumbens-associated protein 1
NCBI Official Synonym Full Names
nucleus accumbens associated 1
NCBI Official Symbol
NACC1
NCBI Official Synonym Symbols
NAC1; BEND8; NAC-1; NECFM; BTBD30; BTBD14B
NCBI Protein Information
nucleus accumbens-associated protein 1
UniProt Protein Name
Nucleus accumbens-associated protein 1
UniProt Gene Name
NACC1
UniProt Synonym Gene Names
BTBD14B; NAC1; NAC-1
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Product Notes
The NAC1 nacc1 (Catalog #AAA108653) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The NAC1 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's NAC1 can be used in a range of immunoassay formats including, but not limited to, ELISA, IHC (Immunohistochemistry), WB (Western Blot). Researchers should empirically determine the suitability of the NAC1 nacc1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "NAC1, Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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