Mouse CD62P Antibody | anti-CD62P antibody
Anti-Hu CD62P Purified Low Endotoxin
Gene Names
SELP; CD62; GRMP; PSEL; CD62P; GMP140; LECAM3; PADGEM
Reactivity
Human, Non-human primates
Applications
Functional Assay, Immunocytochemistry, Western Blot, Immunoprecipitation, Flow Cytometry, Functional Assay
Purity
Purified by Protein-A Affinity Chromatography
Synonyms
CD62P; N/A; Anti-Hu CD62P Purified Low Endotoxin; selectin P; P-selectin; GMP140; SELP; PADGEM; GRMP; LECAM3; PSEL; anti-CD62P antibody
Host
Mouse
Reactivity
Human, Non-human primates
Isotype
IgG1 kappa
Clone Number
AK4
Specificity
The antibody AK4 recognizes an extracellular epitope of CD62P (P-selectin), a 140 kD single chain type I transmembrane glycoprotein present in secretory alpha-granules in platelets, in Weibel-Palade bodies in endothelial cells and in megakaryocytes; it is relocated to the plasma membrane upon activation.
Purity/Purification
Purified by Protein-A Affinity Chromatography
Form/Format
Low endotoxin azide free phosphate buffered saline (PBS) solution, 0.2 um filter sterilized. Endotoxin level is less than 0.01 EU/ug of the protein, as determined by the LAL test.
Concentration
1 mg/ml (varies by lot)
Sequence Length
830
Applicable Applications for anti-CD62P antibody
FA (Functional Assay), ICC (Immunocytochemistry), WB (Western Blot), IP (Immunoprecipitation), FCM/FACS (Flow Cytometry)
Immunogen
Human platelets
Preparation and Storage
Store at 2-8 degree C.
Related Product Information for anti-CD62P antibody
CD62P (P-selectin) is an adhesion glycoprotein that is expressed on platelets and endothelial cells upon their activation. Interaction between CD62P and its mucin-like ligand PSGL-1 (P-selectin glycoprotein ligand-1) expressed on the microvilli of most leukocytes supports leukocyte rolling along postkapillary venules at the earliest time of inflammation. Both CD62P and PSGL-1 are extended glycoproteins that form homodimers. CD62P dimerization is probably mediated through interactions of the transmembrane domains and stabilizes leukocyte tethering and rolling, probably by increasing rebinding within a bond cluster.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
UniProt Accession #
NCBI Official Full Name
granule membrane protein-140
NCBI Official Synonym Full Names
selectin P
NCBI Official Symbol
SELP
NCBI Official Synonym Symbols
CD62; GRMP; PSEL; CD62P; GMP140; LECAM3; PADGEM
NCBI Protein Information
P-selectin
UniProt Protein Name
P-selectin
UniProt Gene Name
SELP
UniProt Synonym Gene Names
GMRP; GRMP; GMP-140; LECAM3; PADGEM
UniProt Entry Name
LYAM3_HUMAN
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Product Notes
The CD62P selp (Catalog #AAA128415) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Anti-Hu CD62P Purified Low Endotoxin reacts with Human, Non-human primates and may cross-react with other species as described in the data sheet. AAA Biotech's CD62P can be used in a range of immunoassay formats including, but not limited to, FA (Functional Assay), ICC (Immunocytochemistry), WB (Western Blot), IP (Immunoprecipitation), FCM/FACS (Flow Cytometry). Researchers should empirically determine the suitability of the CD62P selp for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD62P, Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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