MYD88 recombinant protein

MyD88 Fragment Recombinant Protein

Cat. Num. AAA40473

• Gene Names: MYD88; MYD88D
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: ~95%
• Synonyms: MyD88; N/A; MyD88 Fragment Recombinant Protein; MyD88 Antibody : MYD88D; myeloid differentiation primary response gene (88); MYD88 recombinant protein

• Host: E. Coli
• Reactivity: Human
• Purity/Purification: ~95%
• Form/Format: Liquid; 1X PBS containing 0.1% SDS and 0.02% NaN₃
• Sequence: aa 176 - 280
• Sequence Length: 296

• Applicable Applications for MYD88 recombinant protein: WB (Western Blot), ELISA
• Fusion Tag: Fusion Partner: His-tag and strepII-tag at N-terminus
• Preparation and Storage: Store in working aliquots at -70°C.; Avoid freeze/thaw cycles. ; When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.; ; Shipping: Dry Ice.

SDS-PAGE

(MyD88 Fragment Recombinant Protein)

Related Product Information for MYD88 recombinant protein

The pro-inflammatory cytokine IL-1 induced cellular response requires IL-1 receptor complex including IL-1RI and IL-1RAcP. MyD88 has been identified as an adapter molecule in the IL-1 signaling pathway (1). MyD88 associates with and recruits IRAK to the IL-1 receptor complex in response to IL-1 treatment and dominant negative form of MyD88 attenuates IL-1R-mediated NF-?B activation. MyD88 is also employed as a regulator molecule by IL-18 receptor and human Toll receptor (2,3), which are members in the Toll/IL-1R family of receptors. Targeted disruption of the MyD88 gene results in lose of cellular responses to IL-1 and IL-18, and MyD88-deficient mice lack responses to bacterial product LPS that employs Toll-like receptors 2 and 4 (TLR2 and TLR4) as the signaling receptors. MyD88 is a general adapter protein for the Toll/IL-1R family of receptors and plays an important role in the inflammatory response induced by cytokines IL-1 and IL-18 and endotoxin. MyD88 gene is expressed in many tissues.

NCBI and Uniprot Product Information

• NCBI GI #: 1814020
• NCBI GeneID: 4615
• UniProt Accession #: Q99836; P78397; Q53XS7; B4DKH8; B4DKU4; B4DQ60; B4DQ72; J3KPU4; J3KQ87; J3KQJ6
• Molecular Weight: 15 kDa (Calculated)
• NCBI Official Full Name: MyD88
• NCBI Official Synonym Full Names: myeloid differentiation primary response 88
• NCBI Official Symbol: MYD88
• NCBI Official Synonym Symbols: MYD88D
• NCBI Protein Information: myeloid differentiation primary response protein MyD88; myeloid differentiation primary response gene (88)
• UniProt Protein Name: Myeloid differentiation primary response protein MyD88
• UniProt Gene Name: MYD88
• UniProt Entry Name: MYD88_HUMAN