SDS-PAGE
Nectin-4/PVRL4 Recombinant Protein | PVRL4 recombinant protein
Recombinant Human Nectin-4/PVRL4 Protein (C-6His)
Gene Names
NECTIN4; LNIR; PRR4; EDSS1; PVRL4; nectin-4
Purity
>95% as determined by reducing SDS-PAGE.
Synonyms
Nectin-4/PVRL4; N/A; Recombinant Human Nectin-4/PVRL4 Protein (C-6His); PVRL4; Nectin-4; Ig superfamily receptor LNIR; Poliovirus receptor-related protein 4; PRR4; LNIR; PVRL4 recombinant protein
Host
Human Cells
Purity/Purification
>95% as determined by reducing SDS-PAGE.
Form/Format
Lyophilized from a 0.2 um filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
Sequence Positions
Gly31-Val351
Sequence Length
510
Species
Human
Endotoxin
<1.0 EU per ug as determined by LAL test method.
Tag
C-6His
Biological Activity
Immunobulized Anti-Human Nectin-4 mAb-mFc at 2ug/mL (100 ul/well) can bind Human Nectin-4-His. The ED50 of Human Nectin-4-His is 16.29 ng/mL
Reconstitution
We recommend that the vial be centrifuged to opening to bring the contents to the bottom. Do not mix by vortex.
It is recommended that the sterile water be added to the vial to prepare a stock soultion of 0.25mg/mL. Concentration is measured by UV-Vis.
It is recommended that the sterile water be added to the vial to prepare a stock soultion of 0.25mg/mL. Concentration is measured by UV-Vis.
Preparation and Storage
Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
SDS-PAGE
SDS-PAGE
Related Product Information for PVRL4 recombinant protein
Nectin-4 (PVRL4) is a type I transmembrane glycoprotein which belongs to the nectin family of Ig superfamily proteins. It contains two Ig-like C2-type domains and one Ig-like V-type domain. PVRL4 seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with nectin-1. It does not act as receptor for alpha-herpesvirus entry into cells. It is predominantly expressed in placenta, the embryo and breast carcinoma. But it is not detected in normal breast epithelium. The soluble form is produced by proteolytic cleavage at the cell surface (shedding), probably by ADAM17. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
Molecular Mass: 35.3 kDa
Actual Protein Molecular Mass: 40-47 kDa
Actual Protein Molecular Mass: 40-47 kDa
NCBI Official Full Name
nectin-4
NCBI Official Synonym Full Names
nectin cell adhesion molecule 4
NCBI Official Symbol
NECTIN4
NCBI Official Synonym Symbols
LNIR; PRR4; EDSS1; PVRL4; nectin-4
NCBI Protein Information
nectin-4
UniProt Protein Name
Nectin-4
UniProt Gene Name
NECTIN4
UniProt Synonym Gene Names
LNIR; PRR4; PVRL4
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Product Notes
The PVRL4 nectin4 (Catalog #AAA174025) is a Recombinant Protein produced from Human Cells and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is Gly31-Val351. It is sometimes possible for the material contained within the vial of "Nectin-4/PVRL4, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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