Ubiquitin Aldehyde Binding 1 Recombinant Protein | OTUB1 recombinant protein

Recombinant Human Ubiquitin Aldehyde Binding 1

Cat. Num. AAA38764

• Gene Names: OTUB1; OTB1; OTU1; HSPC263
• Purity: Greater than 95.0% as determined by SDS-PAGE.
• Synonyms: Ubiquitin Aldehyde Binding 1; N/A; Recombinant Human Ubiquitin Aldehyde Binding 1; OTUB1 Human; Ubiquitin Aldehyde Binding 1 Human Recombinant; Ubiquitin thioesterase OTUB1; Otubain-1; OTU domain-containing ubiquitin aldehyde-binding protein 1; Ubiquitin-specific-processing protease OTUB1; Deubiquitinating enzyme OTUB1; OTUB1; OTB1; OTU1; HSPC263; MGC4584; FLJ20113; FLJ40710; MGC111158; OTUB1 recombinant protein

• Host: E Coli
• Purity/Purification: Greater than 95.0% as determined by SDS-PAGE.
• Form/Format: The OTUB1 solution contains 20mM Tris buffer (pH 8.0) and 10% glycerol.; Sterile Filtered colorless solution.
• Sequence: MGSSHHHHHH SSGLVPRGSHMAAEEPQQQK QEPLGSDSEG VNCLAYDEAI MAQQDRIQQE IAVQNPLVSE RLELSVLYKE YAEDDNIYQQ KIKDLHKKYS YIRKTRPDGN CFYRAFGFSH LEALLDDSKE LQRFKAVSAK SKEDLVSQGF TEFTIEDFHN TFMDLIEQVE KQTSVADLLA SFNDQSTSDY LVVYLRLLTS GYLQRESKFF EHFIEGGRTV KEFCQQEVEP MCKESDHIHI IALAQALSVS IQVEYMDRGE GGTTNPHIFP EGSEPKVYLL YRPGHYDILY K
• Sequence Length: 271

• Preparation and Storage: Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

Related Product Information for OTUB1 recombinant protein

Description: OTUB1 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E Coli is a single, non-glycosylated, polypeptide chain containing 291 amino acids (1- 271 a.a.) and having a molecular mass of 33.4kDa.The OTUB1 is purified by proprietary chromatographic techniques.

Introduction: Otubain 1 (OTUB1) belongs to the ovarian tumor (OUT) superfamily of predicted cysteine proteases and inhibits cytokine gene transcription in the immune system through its interaction with a ubiquitin protease and E3 ubiquitin ligase. OTUB1 is a highly specific ubiquitin iso-peptidase, it cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitinated substrates. OTUB1 is believed to work in specific ubiquitin-dependent pathways, possibly by providing an editing function of polyubiquitin chain growth. OTUB1 is a hydrolase that removes conjugated ubiquitin from proteins in vitro and may therefore have a significant regulatory role in the level of protein turnover by preventing degradation. Additionally, OTUB1 is a regulator of T-cell anergy, a phenomenon that occurs when T-cells are rendered impassive to antigen re-challenge and no longer respond to their cognate antigen. OTUB1 acts via its interaction with RNF128/GRAIL, which is an essential inductor of CD4 T-cell anergy.

Product Categories/Family for OTUB1 recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins; Ubiquitin

NCBI and Uniprot Product Information

• NCBI GI #: 109148508
• NCBI GeneID: 55611
• NCBI Accession #: NP_060140.2
• NCBI GenBank Nucleotide #: NM_017670.2
• UniProt Accession #: Q96FW1; Q32Q78; Q96II3; Q9NXQ4; Q9P0B8
• Molecular Weight: 35,285 Da
• NCBI Official Full Name: ubiquitin thioesterase OTUB1
• NCBI Official Synonym Full Names: OTU deubiquitinase, ubiquitin aldehyde binding 1
• NCBI Official Symbol: OTUB1
• NCBI Official Synonym Symbols: OTB1; OTU1; HSPC263
• NCBI Protein Information: ubiquitin thioesterase OTUB1; OTU domain, ubiquitin aldehyde binding 1; OTU domain-containing ubiquitin aldehyde-binding protein 1; OTU-domain Ubal-binding 1; deubiquitinating enzyme OTUB1; otubain-1; ubiquitin-specific protease otubain 1; ubiquitin-specific-processing protease OTUB1
• UniProt Protein Name: Ubiquitin thioesterase OTUB1
• UniProt Gene Name: OTUB1
• UniProt Synonym Gene Names: OTB1; OTU1; hOTU1
• UniProt Entry Name: OTUB1_HUMAN