<
IHC (Immunohistochemistry)
(ACE2/ACE-2 Antibody-Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE))
Rabbit anti-Human ACE2/ACE-2 Polyclonal Antibody | anti-ACE2 antibody
ACE2/ACE-2 Rabbit anti-Human Polyclonal Antibody
Gene Names
ACE2; ACEH
Reactivity
Human
Applications
ELISA, Immunohistochemistry, Western Blot
Purity
Immunoaffinity purified
Synonyms
ACE2/ACE-2; Polyclonal Antibody; ACE2/ACE-2 Rabbit anti-Human Polyclonal Antibody; PathPlus ACE2/ACE-2 Antibody; ACE2; ACE-related carboxypeptidase; ACEH; Metalloprotease MPROT15; SARS-CoV2 Coronavirus Receptor; SARS-CoV-2 Coronavirus Receptor; COVID-19 viral receptor; anti-ACE2 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Purity/Purification
Immunoaffinity purified
Form/Format
PBS, 0.1% Sodium Azide
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-ACE2 antibody
ELISA (EIA), Immunohistochemistry-Paraffin (IHC-P), Western Blot (WB)
Target
Human ACE2/ACE-2
Immunogen
LP-13632, synthetic peptide
Conjugation
Unconjugated
Family
Protease
Subfamily
Metallopeptidase M2
Preparation and Storage
Aliquot and store undiluted at -20 degree C or below for up to 1 year. Can be stored undiluted at 4 degree C for up to 1 month. Avoid freeze-thaw cycles.
IHC (Immunohistochemistry)
(ACE2/ACE-2 Antibody-Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohistochemistry)
(ACE2/ACE-2 Antibody-Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohistchemistry)
(ACE2/ACE-2 Antibody-Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohistchemistry)
(ACE2/ACE-2 Antibody-Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohistochemistry)
(ACE2/ACE-2 Antibody-Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohistochemistry)
(ACE2/ACE-2 Antibody-Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE))
WB (Western Blot)
(ACE2/ACE-2 Antibody-Capillary Western Analysis of anti-ACE2 antibody (AAA21385, 20 ug/mL) using 12-230 kDa separation module. Lane 1: no sample negative control; Lane 2: 1.875ug whole human kidney lysate (positive control), Lane 3: 1.875ug whole human brain lysate (negative control). Antibody produced a predominant ~63kDa and minor ~58kDa band in the kidney, and no banding in the brain. (Protein Simple Virtual Blot))
WB (Western Blot)
(ACE2/ACE-2 Antibody-Capillary Western Analysis of anti-ACE2 antibody (AAA21385, 20 ug/mL) using 12-230 kDa separation module. Lane 1: no sample negative control; Lane 2: 1.875ug whole human kidney lysate (positive control), Lane 3: 1.875ug whole human brain lysate (negative control). Antibody produced a predominant ~63kDa and minor ~58kDa band in the kidney, and no banding in the brain. (Protein Simple Virtual Blot))
Application Data
(ACE2/ACE-2 Antibody-Capillary Western Analysis of anti-ACE2 antibody (AAA21385, 20 ug/mL) using 12-230 kDa separation module. Lane 1: no sample negative control; Lane 2: 1.875ug whole human kidney lysate (positive control), Lane 3: 1.875ug whole human brain lysate (negative control). Antibody produced a predominant ~63kDa and minor ~58kDa band in the kidney, and no banding in the brain. (Protein Simple Electropherogram))
Application Data
(ACE2/ACE-2 Antibody-Capillary Western Analysis of anti-ACE2 antibody (AAA21385, 20 ug/mL) using 12-230 kDa separation module. Lane 1: no sample negative control; Lane 2: 1.875ug whole human kidney lysate (positive control), Lane 3: 1.875ug whole human brain lysate (negative control). Antibody produced a predominant ~63kDa and minor ~58kDa band in the kidney, and no banding in the brain. (Protein Simple Electropherogram))
Application Data
(ACE2/ACE-2 Antibody-Western Blot: AAA21385 (1:100) vs. full-length recombinant human ACE2 protein. Lane 7: 50 ng, Lane 8: 100 ng, Lane 9 500ng. Detection fluorescent conjugated anti-rabbit secondary antibody (1:100).)
Application Data
(ACE2/ACE-2 Antibody-Western Blot: AAA21385 (1:100) vs. full-length recombinant human ACE2 protein. Lane 7: 50 ng, Lane 8: 100 ng, Lane 9 500ng. Detection fluorescent conjugated anti-rabbit secondary antibody (1:100).)
ELISA
(ACE2/ACE-2 Antibody-Indirect detection ELISA against full length Recombinant Human ACE2. Primary antibody was diluted 1:100 (10ug/mL final concentration). Secondary goat anti-rabbit HRP conjugated antibody was diluted 1:100.)
ELISA
(ACE2/ACE-2 Antibody-Indirect detection ELISA against full length Recombinant Human ACE2. Primary antibody was diluted 1:100 (10ug/mL final concentration). Secondary goat anti-rabbit HRP conjugated antibody was diluted 1:100.)
Related Product Information for anti-ACE2 antibody
ACE-2 antibody is an unconjugated rabbit polyclonal antibody to ACE-2 (ACE2) from human. Validated for ELISA, IHC and WB. Tested on 20 paraffin-embedded human tissues.
Angiotensin-Converting Enzyme 2 (ACE2) is a transmembrane protein found in the lungs, intestines, heart, kidney, liver and arteries that plays a central role in vascular, renal, and myocardial physiology. The normal function of ACE2 is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7. It is involved in controlling vascular function including blood pressure, and absence of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function. ACE2 is also the primary attachment receptor for HCoV-N63, SARS-CoV and SARS-CoV-2. The S1 portion of the coronavirus spike protein attaches to ACE2 presented on the host cell surface. The SARS-CoV-2 virus targets pneumocytes and macrophages expressing ACE2 in the lung, and it is believed to infect ACE2-positive cells in other tissues including the gastrointestinal tract and potentially the liver (in cholangiocytes).
Angiotensin-Converting Enzyme 2 (ACE2) is a transmembrane protein found in the lungs, intestines, heart, kidney, liver and arteries that plays a central role in vascular, renal, and myocardial physiology. The normal function of ACE2 is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7. It is involved in controlling vascular function including blood pressure, and absence of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function. ACE2 is also the primary attachment receptor for HCoV-N63, SARS-CoV and SARS-CoV-2. The S1 portion of the coronavirus spike protein attaches to ACE2 presented on the host cell surface. The SARS-CoV-2 virus targets pneumocytes and macrophages expressing ACE2 in the lung, and it is believed to infect ACE2-positive cells in other tissues including the gastrointestinal tract and potentially the liver (in cholangiocytes).
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
92,463 Da
NCBI Official Full Name
angiotensin-converting enzyme 2
NCBI Official Synonym Full Names
angiotensin I converting enzyme 2
NCBI Official Symbol
ACE2
NCBI Official Synonym Symbols
ACEH
NCBI Protein Information
angiotensin-converting enzyme 2; peptidyl-dipeptidase A; metalloprotease MPROT15; ACE-related carboxypeptidase; angiotensin-converting enzyme homolog; angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
UniProt Protein Name
Angiotensin-converting enzyme 2
UniProt Gene Name
ACE2
UniProt Synonym Gene Names
ACEH
UniProt Entry Name
ACE2_HUMAN
Similar Products
Product Notes
The ACE2 ace2 (Catalog #AAA21385) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ACE2/ACE-2 Rabbit anti-Human Polyclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's ACE2/ACE-2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry-Paraffin (IHC-P), Western Blot (WB). Researchers should empirically determine the suitability of the ACE2 ace2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ACE2/ACE-2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
