Rabbit anti-Human AIF Polyclonal Antibody | anti-CNKSR1 antibody

AIF Antibody

Cat. Num. AAA39339

• Gene Names: CNKSR1; CNK; CNK1
• Reactivity: Human
• Applications: Immunofluorescence, Immunocytochemistry, Western Blot, ELISA
• Purity: AIF Antibody is Ion exchange chromatography purified.
• Synonyms: AIF, Antibody; AIF Antibody; AIF; CNK; KSR; CNK1; Connector enhancer of kinase suppressor of ras 1; CNK homolog protein 1; Connector enhancer of KSR 1; connector enhancer of kinase suppressor of Ras 1; anti-CNKSR1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: AIF Antibody is Ion exchange chromatography purified.
• Form/Format: Liquid
• Sequence Length: 720

• Applicable Applications for anti-CNKSR1 antibody: IF (Immunofluorescence), ICC (Immunocytochemistry), WB (Western Blot), ELISA
• Conjugate: Unconjugated
• Immunogen: AIF antibody was raised against a peptide corresponding to amino acids near the amino terminus of mature human AIF.
• Buffer: AIF Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: AIF antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IF (Immunofluorescence)

(Immunofluorescence of AIF in K562 cells with AIF antibody at 20 μg/mL.)

ICC (Immunocytochemistry)

(Immunocytochemistry of AIF in Jurkat cells with AIF antibody at 2 μg/mL.)

WB (Western Blot)

(Western blot analysis of AIF in K562 cell lysate with AIF antibody at 1 μg/mL.)

Related Product Information for anti-CNKSR1 antibody

AIF Antibody: Apoptosis is characterized by several morphological nuclear changes including chromatin condensation and nuclear fragmentation. These changes are triggered by the activation of members of caspase family, caspase activated DNase, and several novel proteins. A novel gene, the product of which causes chromatin condensation and DNA fragmentation, was recently identified, cloned, and designated apoptosis inducing factor (AIF). Like the critical molecules, cytochrome c and caspase-9, in apoptosis, AIF localizes in mitochondria. AIF translocates to the nucleus when apoptosis is induced and induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. AIF induces chromatin condensation and DNA fragmentation, which are the hallmarks of apoptosis, of the isolated nucleus and the nucleus in live cells by microinjection. AIF is highly conserved between human and mouse and widely expressed.

NCBI and Uniprot Product Information

• NCBI GI #: 50400606
• NCBI GeneID: 10256
• UniProt Accession #: O95381; B1AMW9; Q969H4
• Molecular Weight: 67 kDa
• NCBI Official Full Name: Connector enhancer of kinase suppressor of ras 1
• NCBI Official Synonym Full Names: connector enhancer of kinase suppressor of Ras 1
• NCBI Official Symbol: CNKSR1
• NCBI Official Synonym Symbols: CNK; CNK1
• NCBI Protein Information: connector enhancer of kinase suppressor of ras 1; CNK homolog protein 1; connector enhancer of KSR 1
• UniProt Protein Name: Connector enhancer of kinase suppressor of ras 1
• UniProt Gene Name: CNKSR1
• UniProt Synonym Gene Names: CNK1; Connector enhancer of KSR 1; CNK1; hCNK1
• UniProt Entry Name: CNKR1_HUMAN