IF (Immunofluorescence)
(Confocal immunofluorescent analysis of AIRE Antibody (Center) with 293 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).)
Rabbit anti-Human, mouse AIRE Polyclonal Antibody | anti-AIRE antibody
AIRE Antibody (Center)
Gene Names
AIRE; APS1; APSI; PGA1; AIRE1; APECED
Reactivity
Human, mouse
Applications
Immunofluorescence, ELISA, Western Blot
Purity
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
AIRE, Antibody; AIRE Antibody (Center); Autoimmune regulator; Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein; APECED protein; AIRE; APECED; anti-AIRE antibody
Host
Rabbit
Reactivity
Human, mouse
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This AIRE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 64-92 amino acids from the Central region of human AIRE.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.5 (varies by lot)
Sequence Positions
64-92
Sequence Length
348
Applicable Applications for anti-AIRE antibody
IF (Immunofluorescence), ELISA, WB (Western Blot)
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
IF (Immunofluorescence)
(Confocal immunofluorescent analysis of AIRE Antibody (Center) with 293 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).)
IF (Immunofluorescence)
(Confocal immunofluorescent analysis of AIRE Antibody (Center) with 293 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).)
WB (Western Blot)
(AIRE Antibody (Center) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the AIRE antibody detected the AIRE protein (arrow).)
WB (Western Blot)
(AIRE Antibody (Center) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the AIRE antibody detected the AIRE protein (arrow).)
Related Product Information for anti-AIRE antibody
This gene encodes a transcriptional regulator that forms
nuclear bodies and interacts with the transcriptional coactivator
CBP. At least three splice variant mRNAs products have been
described including one which results in a premature stop codon and
a transcript predicted to be a candidate for nuclear-mediated decay
(NMD). Defects in this gene cause the rare autosomal-recessive
systemic autoimmune disease termed autoimmune
polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).
nuclear bodies and interacts with the transcriptional coactivator
CBP. At least three splice variant mRNAs products have been
described including one which results in a premature stop codon and
a transcript predicted to be a candidate for nuclear-mediated decay
(NMD). Defects in this gene cause the rare autosomal-recessive
systemic autoimmune disease termed autoimmune
polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).
Product Categories/Family for anti-AIRE antibody
References
Cervato, S., et al. Clin. Endocrinol. (Oxf) 73(5):630-636(2010)
Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010)
Conteduca, G., et al. Clin. Immunol. 136(1):96-104(2010)
Colome, N., et al. J. Proteome Res. 9(5):2600-2609(2010)
Gu, B., et al. Biochem. Biophys. Res. Commun. 394(2):418-423(2010)
Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010)
Conteduca, G., et al. Clin. Immunol. 136(1):96-104(2010)
Colome, N., et al. J. Proteome Res. 9(5):2600-2609(2010)
Gu, B., et al. Biochem. Biophys. Res. Commun. 394(2):418-423(2010)
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
57727
NCBI Official Full Name
autoimmune regulator
NCBI Official Synonym Full Names
autoimmune regulator
NCBI Official Symbol
AIRE
NCBI Official Synonym Symbols
APS1; APSI; PGA1; AIRE1; APECED
NCBI Protein Information
autoimmune regulator
UniProt Protein Name
Autoimmune regulator
UniProt Gene Name
AIRE
UniProt Synonym Gene Names
APECED; APECED protein
UniProt Entry Name
AIRE_HUMAN
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Product Notes
The AIRE aire (Catalog #AAA287732) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 64-92. The AIRE Antibody (Center) reacts with Human, mouse and may cross-react with other species as described in the data sheet. AAA Biotech's AIRE can be used in a range of immunoassay formats including, but not limited to, IF (Immunofluorescence), ELISA, WB (Western Blot). Researchers should empirically determine the suitability of the AIRE aire for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "AIRE, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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