Rabbit anti-Human AKAP10 Polyclonal Antibody | anti-AKAP10 antibody

Rabbit anti-human AKAP10 polyclonal Antibody

Cat. Num. AAA118337

• Gene Names: AKAP10; PRKA10; AKAP-10; D-AKAP2; D-AKAP-2
• Reactivity: Human
• Applications: Immunohistochemistry, Western Blot, ELISA
• Purity: Antigen Affinity Purified
• Synonyms: AKAP10, Antibody; Rabbit anti-human AKAP10 polyclonal Antibody; AKAP-10; Dual specificity A kinase-anchoring protein 2; D-AKAP-2; Protein kinase A-anchoring protein 10; PRKA10; AKAP10; anti-AKAP10 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen Affinity Purified
• Sequence Length: 662

• Applicable Applications for anti-AKAP10 antibody: IHC (Immunohistochemistry), WB (Western Blot), ELISA
• Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Conjugate: Non-conjugated
• Immunogen: Recombinant human A-kinase anchor protein 10, mitochondrial protein (413-662aa)
• Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-109187 / sc-109188 / sc-109189 / sc-98755
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

IHC (Immunohistochemisry)

(Immunohistochemistry of paraffin-embedded human cervical cancer using AAA118337 at dilution 1:100)

IHC (Immunohiostchemistry)

(Immunohistochemistry of paraffin-embedded human breast cancer using AAA118337 at dilution 1:100)

WB (Western Blot)

(All lanes: AKAP10 antibody at 7ug/mlLane 1:293T whole cell lysateLane 2:Hela whole cell lysateLane 3:HepG2 whole cell lysateSecondaryGoat polyclonal to rabbit at 1/10000 dilutionPredicted band size: 74kDaObserved band size: 74kDa)

Related Product Information for anti-AKAP10 antibody

Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase (By similarity).

NCBI and Uniprot Product Information

• NCBI GI #: 21493033
• NCBI GeneID: 11216
• NCBI Accession #: NP_009133.2
• NCBI GenBank Nucleotide #: NM_007202.3
• UniProt Accession #: O43572; Q96AJ7; B2R650
• Molecular Weight: 73,818 Da
• NCBI Official Full Name: A-kinase anchor protein 10, mitochondrial
• NCBI Official Synonym Full Names: A-kinase anchoring protein 10
• NCBI Official Symbol: AKAP10
• NCBI Official Synonym Symbols: PRKA10; AKAP-10; D-AKAP2; D-AKAP-2
• NCBI Protein Information: A-kinase anchor protein 10, mitochondrial
• UniProt Protein Name: A-kinase anchor protein 10, mitochondrial
• UniProt Gene Name: AKAP10
• UniProt Synonym Gene Names: AKAP-10; D-AKAP-2; PRKA10
• UniProt Entry Name: AKA10_HUMAN