IF (Immunofluorescence)
(Immunofluorescence analysis of U20S cell using ARRB2 antibody. Blue: DAPI for nuclear staining.)
Rabbit ARRB2 Polyclonal Antibody | anti-ARRB2 antibody
ARRB2 antibody
Gene Names
ARRB2; ARB2; ARR2; BARR2
Reactivity
Human, Mouse, Rat
Applications
Immunofluorescence, Western Blot
Purity
Antibodies were purified by affinity purification using immunogen.
Synonyms
ARRB2, Antibody; ARRB2 antibody; ARRB2; ARB2; ARR2; BARR2; DKFZp686L0365; Beta Arrestin 2; anti-ARRB2 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Specificity
The antibody detects endogenous level of total ARRB2 antibody.
Purity/Purification
Antibodies were purified by affinity purification using immunogen.
Form/Format
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1.0 mg/ml (varies by lot)
Sequence Length
430
Applicable Applications for anti-ARRB2 antibody
IF (Immunofluorescence), WB (Western Blot)
Immunogen Type
Recombinant Protein
Immunogen Description
Recombinant protein of human ARRB2.
Target Name
ARRB2
Preparation and Storage
Store at -20 degree C
IF (Immunofluorescence)
(Immunofluorescence analysis of U20S cell using ARRB2 antibody. Blue: DAPI for nuclear staining.)
IF (Immunofluorescence)
(Immunofluorescence analysis of U20S cell using ARRB2 antibody. Blue: DAPI for nuclear staining.)
WB (Western Blot)
(Western blot analysis of RAW264.7 cell lysate using ARRB2 antibody.)
WB (Western Blot)
(Western blot analysis of RAW264.7 cell lysate using ARRB2 antibody.)
Related Product Information for anti-ARRB2 antibody
Arrestin proteins function as negative regulators of G protein-coupled receptor (GPCR) signaling. Cognate ligand binding stimulates GPCR phosphorylation, which is followed by binding of arrestin to the phosphorylated GPCR and the eventual internalization of the receptor and desensitization of GPCR signaling (1). Four distinct mammalian arrestin proteins are known. Arrestin 1 (also known as S-arrestin) and arrestin 4 (X-arrestin) are localized to retinal rods and cones, respectively. Arrestin 2 (also known as b-arrestin 1) and arrestin 3 (b-arrestin 2) are ubiquitously expressed and bind to most GPCRs (2). b-arrestins function as adaptor and scaffold proteins and play important roles in other processes, such as recruiting c-Src family proteins to GPCRs in Erk activation pathways (3,4). b-arrestins are also involved in some receptor tyrosine kinase signaling pathways (5-8). Additional evidence suggests that b-arrestins translocate to the nucleus and help regulate transcription by binding transcriptional cofactors (9,10).
Product Categories/Family for anti-ARRB2 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
44,392 Da
NCBI Official Full Name
beta-arrestin-2 isoform 3
NCBI Official Synonym Full Names
arrestin, beta 2
NCBI Official Symbol
ARRB2
NCBI Official Synonym Symbols
ARB2; ARR2; BARR2
NCBI Protein Information
beta-arrestin-2
UniProt Protein Name
Beta-arrestin-2
UniProt Gene Name
ARRB2
UniProt Synonym Gene Names
ARB2; ARR2
UniProt Entry Name
ARRB2_HUMAN
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Product Notes
The ARRB2 arrb2 (Catalog #AAA302408) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ARRB2 antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's ARRB2 can be used in a range of immunoassay formats including, but not limited to, IF (Immunofluorescence), WB (Western Blot). Researchers should empirically determine the suitability of the ARRB2 arrb2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ARRB2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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