IHC (Immunohistochemisry)
(Fig: 3 Immunhistochemical analysis of ASC2/POP1 expression in mouse spleen using at 1: 2000. A and A1, spleen at low and high magnification, respectively. ASC2/POP1 staining is seen in the granulocytes, whereas the lymph and megakaryocytes are negative. )
Rabbit ASC2 Polyclonal Antibody | anti-ASC2 antibody
Polyclonal Antibody to ASC2 (ASC-2/POP)
Gene Names
PYDC1; ASC2; POP1; PYC1; cPOP1
Reactivity
Gerbil, Human, Mouse, Rat
Applications
Immunoprecipitation, Immunohistochemistry, Western Blot
Purity
Serum
Synonyms
ASC2, Antibody; Polyclonal Antibody to ASC2 (ASC-2/POP); PYDC1; ASC2; ASCI; POP1; PYC1; PAAD-only protein 1; Pyrin-only protein 1; cPOP1; cellular POP1; Antibody to ASC2 (ASC-2/POP); Anti-ASC2 (ASC-2/POP) Antibody; ASC2 (ASC-2/POP) Antibody; anti-ASC2 antibody
Host
Rabbit
Reactivity
Gerbil, Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Serum
Form/Format
50 ul sera
Sequence Length
89
Applicable Applications for anti-ASC2 antibody
IP (Immunoprecipitation), IHC (Immunohistochemistry), WB (Western Blot)
Immunogen Information
A full-length recombinant protein of ASC2 (ASC-2/POP) was used as the immunogen for this antibody
Antigen
ASC2 (ASC-2/POP)
Preparation and Storage
Store the antibody at 4 degree C, stable for 6 months.
For long-term storage, store at -20 degree C.
Avoid repeated freeze and thaw cycles.
For long-term storage, store at -20 degree C.
Avoid repeated freeze and thaw cycles.
IHC (Immunohistochemisry)
(Fig: 3 Immunhistochemical analysis of ASC2/POP1 expression in mouse spleen using at 1: 2000. A and A1, spleen at low and high magnification, respectively. ASC2/POP1 staining is seen in the granulocytes, whereas the lymph and megakaryocytes are negative. )
IHC (Immunohistochemisry)
(Fig: 3 Immunhistochemical analysis of ASC2/POP1 expression in mouse spleen using at 1: 2000. A and A1, spleen at low and high magnification, respectively. ASC2/POP1 staining is seen in the granulocytes, whereas the lymph and megakaryocytes are negative. )
IHC (Immunohiostchemistry)
(Fig: 2 Immunhistochemical analysis of ASC2/POP1 expression in mouse using at 1: 2000. A, prostate tissue from a male mouse prostatitis. B, kidney from a mouse with pyelonephritis. A1 and B1, high magnification of A and B, respectively. ASC2/POP1 staining is seen in the granulocytes.)
IHC (Immunohiostchemistry)
(Fig: 2 Immunhistochemical analysis of ASC2/POP1 expression in mouse using at 1: 2000. A, prostate tissue from a male mouse prostatitis. B, kidney from a mouse with pyelonephritis. A1 and B1, high magnification of A and B, respectively. ASC2/POP1 staining is seen in the granulocytes.)
WB (Western Blot)
(Fig: 1 Western blot analysis of ASC2/POP1 using at 1: 2000. HEK-293 cells were transiently transfected with plasmids encoding ASC2, POP1 or a negative control plasmid. ASC2 and POP1 were detected at the expected 12 kDa molecular weight.)
WB (Western Blot)
(Fig: 1 Western blot analysis of ASC2/POP1 using at 1: 2000. HEK-293 cells were transiently transfected with plasmids encoding ASC2, POP1 or a negative control plasmid. ASC2 and POP1 were detected at the expected 12 kDa molecular weight.)
Related Product Information for anti-ASC2 antibody
ASC2/POP1 is a PAAD domain only protein originally identified in a bioinformatics screen aimed at understanding molecular apoptosis mechanisms.Human ASC2/POP1 is an 89 amino acid protein and migrates at ~10-12 kDa on SDS-PAGE gels. ASC2/POP1 has high amino acid sequence homology with ASC (64%), hence it was originally termed ASC2. The PAAD (also known as PYRIN) domain is a conserved sequence motif identified in more than 35 human proteins with putative functions in apoptosis and inflammatory signaling pathways. PAAD was named after the protein families from which it was discovered: pyrin, AIM (absent-in-melanoma), ASC [apoptosis-associated speck-like protein containing a caspase recruitment domain (CARD], and death-domain (DD)-like. In humans, the gene encoding ASC2/POP1 is on chromosome 16p12.1, only 14 kbp away from the ASC locus. The close proximity of ASC2/POP1 to ASC as well as the high sequence homology between them suggest that the ASC2/POP1 and ASC genes arose by gene duplication. Studies have shown that ASC2/POP1 associates with ASC via PADD-PADD interactions and modulates ASC-mediated roles in apoptosis and inflammation. ASC2/POP1 may also have a role in modulating other multidomain PAAD-containing proteins. However, the physiological relevance of ASC2/POP1 remains to be fully elucidated.
Product Categories/Family for anti-ASC2 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
10,107 Da
NCBI Official Full Name
Pyrin domain-containing protein 1
NCBI Official Synonym Full Names
pyrin domain containing 1
NCBI Official Symbol
PYDC1
NCBI Official Synonym Symbols
ASC2; POP1; PYC1; cPOP1
NCBI Protein Information
pyrin domain-containing protein 1
UniProt Protein Name
Pyrin domain-containing protein 1
UniProt Gene Name
PYDC1
UniProt Synonym Gene Names
cPOP1
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Product Notes
The ASC2 pydc1 (Catalog #AAA78297) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to ASC2 (ASC-2/POP) reacts with Gerbil, Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's ASC2 can be used in a range of immunoassay formats including, but not limited to, IP (Immunoprecipitation), IHC (Immunohistochemistry), WB (Western Blot). Researchers should empirically determine the suitability of the ASC2 pydc1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ASC2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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