Rabbit anti-Human BBS10 Polyclonal Antibody | anti-BBS10 antibody

BBS10 Antibody (C-term)

Cat. Num. AAA287534

• Gene Names: BBS10; C12orf58
• Reactivity: Human
• Applications: Flow Cytometry, Functional Assay, ELISA, Western Blot
• Purity: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
• Synonyms: BBS10, Antibody; BBS10 Antibody (C-term); Bardet-Biedl syndrome 10 protein; BBS10; C12orf58; anti-BBS10 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Rabbit Ig
• Specificity: This BBS10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 515-544 amino acids from the C-terminal region of human BBS10.
• Purity/Purification: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
• Form/Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Concentration: Vial Concentration: 0.5 (varies by lot)
• Sequence Positions: 515-544
• Sequence Length: 723

• Applicable Applications for anti-BBS10 antibody: FCM/FACS (Flow Cytometry), ELISA, WB (Western Blot)
• Antigen Type: Synthetic Peptide
• Antigen Source: HUMAN
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

FCM/FACS (Flow Cytometry)

(BBS10 Antibody (C-term) flow cytometric analysis of NCI-H460 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)

WB (Western Blot)

(Western blot analysis of BBS10 Antibody (C-term) in NCI-H460 cell line lysates (35ug/lane). BBS10 (arrow) was detected using the purified Pab.)

Related Product Information for anti-BBS10 antibody

BBS10 is a member of the Bardet-Biedl syndrome (BBS) gene family. Bardet-Biedl syndrome is an autosomal recessive disorder characterized by progressive retinal degeneration, obesity, polydactyly, renal malformation and mental retardation. The proteins encoded by BBS gene family members are structurally diverse and the similar phenotypes exhibited by mutations in BBS gene family members is likely due to their shared roles in cilia formation and function. Many BBS proteins localize to the basal bodies, ciliary axonemes, and pericentriolar regions of cells. BBS proteins may also be involved in intracellular trafficking via microtubule-related transport. The protein encoded by this gene is likely not a ciliary protein but rather has distant sequence homology to type II chaperonins. As a molecular chaperone, this protein may affect the folding or stability of other ciliary or basal body proteins. Inhibition of this protein's expression impairs ciliogenesis in preadipocytes.

Product Categories/Family for anti-BBS10 antibody

Neuroscience

References

Marion, V., et al. Proc. Natl. Acad. Sci. U.S.A. 106(6):1820-1825(2009)
Gerth, C., et al. Vision Res. 48(3):392-399(2008)
White, D.R., et al. Eur. J. Hum. Genet. 15(2):173-178(2007)

NCBI and Uniprot Product Information

• NCBI GI #: 100816407
• NCBI GeneID: 79738
• NCBI Accession #: NP_078961.3
• NCBI GenBank Nucleotide #: NM_024685.3
• UniProt Accession #: Q8TAM1; Q96CW2; Q9H5D2
• Molecular Weight: 80838
• NCBI Official Full Name: Bardet-Biedl syndrome 10 protein
• NCBI Official Synonym Full Names: Bardet-Biedl syndrome 10
• NCBI Official Symbol: BBS10
• NCBI Official Synonym Symbols: C12orf58
• NCBI Protein Information: Bardet-Biedl syndrome 10 protein
• UniProt Protein Name: Bardet-Biedl syndrome 10 protein
• UniProt Gene Name: BBS10
• UniProt Synonym Gene Names: C12orf58
• UniProt Entry Name: BBS10_HUMAN