WB (Western Blot)
(Western blot analysis of extracts from SH-SY5Y? cells, using BHLHE22 Antibody. The lane on the left was treated with blocking peptide.)
Rabbit BHLHE22 Polyclonal Antibody | anti-BHLHE22 antibody
BHLHE22 Antibody
Gene Names
BHLHE22; Beta3; BHLHB5; Beta3a; CAGL85; TNRC20
Reactivity
Human, Mouse, RatPredicted: Pig, Zebrafish, Bovine, Rabbit, Chicken
Applications
Western Blot
Purity
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Synonyms
BHLHE22, Antibody; BHLHE22 Antibody; Basic helix loop helix domain containing class B 5 1 2 5; Basic helix loop helix protein 5; Beta3; Beta3a; BHE22_HUMAN; bHLHB5; bHLHe22; CAGL85; Class B basic helix-loop-helix protein 5; Class E basic helix-loop-helix protein 22; Class II bHLH protein BHLHB5; TNRC20; Trinucleotide repeat containing 20; Trinucleotide repeat-containing gene 20 protein; anti-BHLHE22 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Predicted: Pig, Zebrafish, Bovine, Rabbit, Chicken
Predicted: Pig, Zebrafish, Bovine, Rabbit, Chicken
Clonality
Polyclonal
Isotype
IgG
Specificity
BHLHE22 Antibody detects endogenous levels of BHLHE22.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Form/Format
Liquid; Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (varies by lot)
Sequence Length
381
Applicable Applications for anti-BHLHE22 antibody
WB (Western Blot)
Immunogen
A synthesized peptide derived from human BHLHE22.
Tissue Specificity
Brain-specific, with the highest expression in the cerebellum.
Fragment
Fab Fragment
Conjugate
Unconjugated
Subcellular Location
Nucleus
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
WB (Western Blot)
(Western blot analysis of extracts from SH-SY5Y? cells, using BHLHE22 Antibody. The lane on the left was treated with blocking peptide.)
WB (Western Blot)
(Western blot analysis of extracts from SH-SY5Y? cells, using BHLHE22 Antibody. The lane on the left was treated with blocking peptide.)
WB (Western Blot)
(Western blot analysis of extracts from Rat brain, using BHLHE22 Antibody. The lane on the left was treated with blocking peptide.)
WB (Western Blot)
(Western blot analysis of extracts from Rat brain, using BHLHE22 Antibody. The lane on the left was treated with blocking peptide.)
Related Product Information for anti-BHLHE22 antibody
Description: Inhibits DNA binding of TCF3/E47 homodimers and TCF3 (E47)/NEUROD1 heterodimers and acts as a strong repressor of Neurod1 and Myod-responsive genes, probably by heterodimerization with class a basic helix-loop-helix factors. Despite the presence of an intact basic domain, does not bind to DNA (By similarity). In the brain, may function as an area-specific transcription factor that regulates the postmitotic acquisition of area identities and elucidate the genetic hierarchy between progenitors and postmitotic neurons driving neocortical arealization. May be required for the survival of a specific population of inhibitory neurons in the superficial laminae of the spinal chord dorsal horn that may regulate pruritis. Seems to play a crucial role in the retinogenesis, in the specification of amacrine and bipolar subtypes. Forms with PRDM8 a transcriptional repressor complex controlling genes involved in neural development and neuronal differentiation.
Subunit Structure: Interacts with PRDM8.
Subunit Structure: Interacts with PRDM8.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
Observed: 37 kDa
Predicted: 37 kDa
Predicted: 37 kDa
NCBI Official Full Name
class E basic helix-loop-helix protein 22
NCBI Official Synonym Full Names
basic helix-loop-helix family member e22
NCBI Official Symbol
BHLHE22
NCBI Official Synonym Symbols
Beta3; BHLHB5; Beta3a; CAGL85; TNRC20
NCBI Protein Information
class E basic helix-loop-helix protein 22
UniProt Protein Name
Class E basic helix-loop-helix protein 22
UniProt Gene Name
BHLHE22
UniProt Synonym Gene Names
BHLHB5; TNRC20; bHLHe22; bHLHb5
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Product Notes
The BHLHE22 bhlhe22 (Catalog #AAA328788) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The BHLHE22 Antibody reacts with Human, Mouse, Rat Predicted: Pig, Zebrafish, Bovine, Rabbit, Chicken and may cross-react with other species as described in the data sheet. AAA Biotech's BHLHE22 can be used in a range of immunoassay formats including, but not limited to, WB (Western Blot). Researchers should empirically determine the suitability of the BHLHE22 bhlhe22 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "BHLHE22, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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