Rabbit BRCA1 Polyclonal Antibody | anti-BRCA1 antibody

BRCA1 Polyclonal Antibody

Cat. Num. AAA30550

• Gene Names: BRCA1; IRIS; PSCP; BRCAI; BRCC1; PNCA4; RNF53; BROVCA1; PPP1R53
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry, Immunofluorescence
• Purity: Affinity purification
• Synonyms: BRCA1; Polyclonal Antibody; BRCA1 Polyclonal Antibody; BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53; anti-BRCA1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity purification
• Form/Format: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH7.4, 150mM NaCl, 0.02% sodium azide and 187% glycerol.; PBS with 0.02% sodium azide, 50% glycerol, pH7.140
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-BRCA1 antibody: Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Application Notes: WB: 1:500-1:2000; IHC: 1:50-1:200; IF: 1:50-1:200
• Immunogen: A synthetic peptide of human BRCA1
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

IHC (Immunohistochemistry)

(Immunohistochemistry of paraffin-embedded mouse spinal cord using BRCA1 antibody at dilution of 1:100 .)

IHC (Immunohistchemistry)

(Immunohistochemistry of paraffin-embedded mouse testis using BRCA1 antibody at dilution of 1:100 .)

IHC (Immunohistochemistry)

(Immunohistochemistry of paraffin-embedded mouse liver using BRCA1 antibody at dilution of 1:100 .)

IHC (Immunohistochemistry)

(Immunohistochemistry of paraffin-embedded rat pancreas using BRCA1 antibody at dilution of 1:100 .)

IHC (Immunohistchemistry)

(Immunohistochemistry of paraffin-embedded rat brain using BRCA1 antibody at dilution of 1:100 .)

IHC (Immunohistochemistry)

(Immunohistochemistry of paraffin-embedded rat ovary using BRCA1 antibody at dilution of 1:100 .)

IHC (Immunohistochemistry)

(Immunohistochemistry of paraffin-embedded rat testis using BRCA1 antibody at dilution of 1:100 .)

WB (Western Blot)

(Western blot analysis of extracts of various cell lines, using BRCA1 antibody at 1:1000 dilution.)

IHC (Immunohistochemistry)

(Immunohistochemistry of paraffin-embedded mouse pancreas using BRCA1 antibody at dilution of 1:100 .)

IHC (Immunohistochemistry)

(Immunohistochemistry of paraffin-embedded human breast cancer using BRCA1 antibody at dilution of 1:100 .)

Related Product Information for anti-BRCA1 antibody

This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified.

Product Categories/Family for anti-BRCA1 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 6552299
• NCBI GeneID: 672
• NCBI Accession #: NP_009225.1
• NCBI GenBank Nucleotide #: NM_007294.3
• UniProt Accession #: P38398; O15129; Q3LRJ0; Q3LRJ6; Q6IN79; Q7KYU9
• Molecular Weight: 207,721 Da
• NCBI Official Full Name: breast cancer type 1 susceptibility protein isoform 1
• NCBI Official Synonym Full Names: breast cancer 1, early onset
• NCBI Official Symbol: BRCA1
• NCBI Official Synonym Symbols: IRIS; PSCP; BRCAI; BRCC1; PNCA4; RNF53; BROVCA1; PPP1R53
• NCBI Protein Information: breast cancer type 1 susceptibility protein; RING finger protein 53; BRCA1/BRCA2-containing complex, subunit 1; protein phosphatase 1, regulatory subunit 53; breast and ovarian cancer susceptibility protein 1; breast and ovarian cancer sususceptibility pr
• UniProt Protein Name: Breast cancer type 1 susceptibility protein
• UniProt Gene Name: BRCA1
• UniProt Synonym Gene Names: RNF53
• UniProt Entry Name: BRCA1_HUMAN