Rabbit BRCC45 Polyclonal Antibody | anti-BRE antibody

BRCC45 Antibody

Cat. Num. AAA39810

• Gene Names: BRE; BRCC4; BRCC45
• Reactivity: Human, Mouse, Rat
• Applications: Immunofluorescence, Immunohistochemistry, Western Blot, ELISA
• Purity: BRCC45 Antibody is affinity chromatography purified via peptide column.
• Synonyms: BRCC45, Antibody; BRCC45 Antibody; BRCC45; BRCC4; BRCA1-A complex subunit BRE; Brain and reproductive organ-expressed protein; brain and reproductive organ-expressed (TNFRSF1A modulator); anti-BRE antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: BRCC45 Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 415

• Applicable Applications for anti-BRE antibody: IF (Immunofluorescence), IHC (Immunohistochemistry), WB (Western Blot), ELISA
• Conjugate: Unconjugated
• Immunogen: BRCC45 antibody was raised against a 18 amino acid synthetic peptide from near the amino terminus of human BRCC45.
• Buffer: BRCC45 Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: BRCC45 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IF (Immunofluorescence)

(Immunofluorescence of BRCC45 in human brain tissue with BRCC45 antibody at 20 μg/mL.)

IHC (Immunohiostchemistry)

(Immunohistochemistry of BRCC45 in human brain tissue with BRCC45 antibody at 2.5 μg/mL.)

WB (Western Blot)

(Western blot analysis of BRCC45 in HeLa cell lysate in (A) the absence and (B) presence of blocking peptide with BRCC45 antibody at 1 μg/mL.)

Related Product Information for anti-BRE antibody

BRCC45 Antibody: BRCC45 was initially suggested to be a housekeeping protein that is highly expressed in brain and reproductive organs. Later experiments indicated BRCC45 forms a complex with the breast and ovarian predisposition proteins BRCA1 and BRCA2 as well as RAD51 and BRCC36. This complex has a ubiquitin E3 ligase activity and is thought to enhance cellular survival following DNA damage. BRCC45 has also been suggested to function as a death receptor-associated anti-apoptotic protein by inhibiting the BID-induced activation of the mitochondrial apoptotic pathway. Higher levels of BRCC45 were detected in the majority of hepatocellular carcinomas, suggesting that BRCC45 may promote tumorigenesis when overexpressed. At least three isoforms of BRCC45 are known to exist.

NCBI and Uniprot Product Information

• NCBI GI #: 21361171
• NCBI GeneID: 9577
• NCBI Accession #: NP_004890
• NCBI GenBank Nucleotide #: NM_004899.4
• UniProt Accession #: Q9NXR7; Q13880; Q4ZFX8; Q53SD0; Q969X9; Q96P06; A8K4X1; D6W562; D6W563
• Molecular Weight: 42,697 Da
• NCBI Official Full Name: BRCA1-A complex subunit BRE isoform 1
• NCBI Official Synonym Full Names: brain and reproductive organ-expressed (TNFRSF1A modulator)
• NCBI Official Symbol: BRE
• NCBI Official Synonym Symbols: BRCC4; BRCC45
• NCBI Protein Information: BRCA1-A complex subunit BRE; BRCA1/BRCA2-containing complex subunit 45; BRCA1/BRCA2-containing complex, subunit 4; brain and reproductive organ-expressed protein
• UniProt Protein Name: BRCA1-A complex subunit BRE
• UniProt Gene Name: BRE
• UniProt Entry Name: BRE_HUMAN