IHC (Immunohiostchemistry)
(Immunohistochemistry of BRCC45 in human brain tissue with BRCC45 antibody at 2.5 ug/mL.)
Rabbit BRCC45 Polyclonal Antibody | anti-BRCC45 antibody
BRCC45 Antibody
Gene Names
BRE; BRCC4; BRCC45
Reactivity
Human, Mouse, Rat
Applications
Immunohistochemistry, Western Blot, ELISA
Purity
Affinity chromatography purified via peptide column
Synonyms
BRCC45, Antibody; BRCC45 Antibody; BRCA1, BRCA2-containing complex subunit 45, Brain and reproductive organ expressed, BRE, TNFRSF1A modulator; anti-BRCC45 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Purity/Purification
Affinity chromatography purified via peptide column
Form/Format
Supplied in PBS containing 0.02% sodium azide.
Sequence Length
415
Applicable Applications for anti-BRCC45 antibody
IHC (Immunohistochemistry), WB (Western Blot), ELISA
Immunogen Type
Peptide
Immunogen Description
Raised against a 18 amino acid peptide from near the amino terminus of human BRCC45.
Target Name
BRCC45
Preparation and Storage
Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
IHC (Immunohiostchemistry)
(Immunohistochemistry of BRCC45 in human brain tissue with BRCC45 antibody at 2.5 ug/mL.)
IHC (Immunohiostchemistry)
(Immunohistochemistry of BRCC45 in human brain tissue with BRCC45 antibody at 2.5 ug/mL.)
WB (Western Blot)
(Western blot analysis of BRCC45 in HeLa cell lysate in (A) the absence and (B) presence of blocking peptide with BRCC45 antibody at 1 ug/mL.)
WB (Western Blot)
(Western blot analysis of BRCC45 in HeLa cell lysate in (A) the absence and (B) presence of blocking peptide with BRCC45 antibody at 1 ug/mL.)
Related Product Information for anti-BRCC45 antibody
BRCC45 was initially suggested to be a housekeeping protein that is highly expressed in brain and reproductive organs. Later experiments indicated BRCC45 forms a complex with the breast and ovarian predisposition proteins BRCA1 and BRCA2 as well as RAD51 and BRCC36. This complex has a ubiquitin E3 ligase activity and is thought to enhance cellular survival following DNA damage. BRCC45 has also been suggested to function as a death receptor-associated anti-apoptotic protein by inhibiting the BID-induced activation of the mitochondrial apoptotic pathway. Higher levels of BRCC45 were detected in the majority of hepatocellular carcinomas, suggesting that BRCC45 may promote tumorigenesis when overexpressed. At least three isoforms of BRCC45 are known to exist.
Product Categories/Family for anti-BRCC45 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
42,697 Da
NCBI Official Full Name
BRCA1-A complex subunit BRE isoform 1
NCBI Official Synonym Full Names
brain and reproductive organ-expressed (TNFRSF1A modulator)
NCBI Official Symbol
BRE
NCBI Official Synonym Symbols
BRCC4; BRCC45
NCBI Protein Information
BRCA1-A complex subunit BRE
UniProt Protein Name
BRCA1-A complex subunit BRE
UniProt Gene Name
BRE
UniProt Entry Name
BRE_HUMAN
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Product Notes
The BRCC45 bre (Catalog #AAA302424) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The BRCC45 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's BRCC45 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), WB (Western Blot), ELISA. Researchers should empirically determine the suitability of the BRCC45 bre for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "BRCC45, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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