Rabbit anti-Human, Mouse BRSK2 Polyclonal Antibody | anti-BRSK2 antibody

BRSK2 Antibody

Cat. Num. AAA39274

• Gene Names: BRSK2; SAD1; SADA; STK29; PEN11B; C11orf7
• Reactivity: Human, Mouse
• Applications: Immunofluorescence, Immunohistochemistry, Western Blot, ELISA
• Purity: BRSK2 Antibody is affinity chromatography purified via peptide column.
• Synonyms: BRSK2, Antibody; BRSK2 Antibody; BRSK2; SAD1; SADA; STK29; PEN11B; C11orf7; HUSSY-12; Brain-selective kinase 2; BR serine/threonine kinase 2; anti-BRSK2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: BRSK2 Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 736

• Applicable Applications for anti-BRSK2 antibody: IF (Immunofluorescence), IHC (Immunohistochemistry), WB (Western Blot), ELISA
• Conjugate: Unconjugated
• Immunogen: BRSK2 antibody was raised against a 23 amino acid synthetic peptide from near the carboxy terminus of human BRSK2.
• Buffer: BRSK2 Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: BRSK2 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IF (Immunofluorescence)

(Immunofluorescence of BRSK2 in Human Brain cells with BRSK2 antibody at 20 μg/mL.)

IHC (Immunohiostchemistry)

(Immunohistochemistry of BRSK2 in human brain tissue with BRSK2 antibody at 5 μg/mL.)

WB (Western Blot)

(Western blot analysis of BRSK2 in human brain tissue lysate with BRSK2 antibody at (A) 0.5, (B) 1 and (C) 2 μg/mL.)

Related Product Information for anti-BRSK2 antibody

BRSK2 Antibody: BRSK2 was initially identified through a computer screen of the human genome and shows significant homology to the C. elegans neuronal cell polarity regulator SAD1. BRSK2 is expressed in the brain and to a lesser extent in the testes. BRSK2 is a member of the AMP-activated protein kinase subfamily and can be activated by the tumor suppressor kinase LKB1. More recently, it has been shown that both BRSK2 and the related protein BRSK1 are required for mammalian neuronal polarization. While BRSK1- and BRSK2-null mice were viable, double-mutant mice died within two hours of birth. Neurons from these mice showed uniformly-sized neurites as opposed to the normal long axon and multiple shorter dendrites. These neurites also displayed both axonal and dendritic markers. BRSK2 has also been shown to be an autoantigen in paraneoplastic limbic encephalitis. At least four isoforms of BRSK2 are known to exist.

NCBI and Uniprot Product Information

• NCBI GI #: 116241272
• NCBI GeneID: 9024
• UniProt Accession #: Q8IWQ3; O60843; O95099; Q5J5B4; Q6ZMQ4; Q8TB60; B3KVE9; E9PLM7
• Molecular Weight: 68,740 Da
• NCBI Official Full Name: Serine/threonine-protein kinase BRSK2
• NCBI Official Synonym Full Names: BR serine/threonine kinase 2
• NCBI Official Symbol: BRSK2
• NCBI Official Synonym Symbols: SAD1; SADA; STK29; PEN11B; C11orf7
• NCBI Protein Information: serine/threonine-protein kinase BRSK2; protein kinase SAD1B; brain-selective kinase 2; serine/threonine-protein kinase 29; BR serine/threonine-protein kinase 2; serine/threonine-protein kinase SAD-A; brain-specific serine/threonine-protein kinase 2
• UniProt Protein Name: Serine/threonine-protein kinase BRSK2
• UniProt Gene Name: BRSK2
• UniProt Synonym Gene Names: C11orf7; PEN11B; SADA; STK29; BR serine/threonine-protein kinase 2
• UniProt Entry Name: BRSK2_HUMAN