IHC (Immunohiostchemistry)
(Immunohistochemical staining of mouse liver tissue using caspase-12 antibody at 2 ug/mL.)
Rabbit Caspase-12 Polyclonal Antibody | anti-Casp12 antibody
Caspase-12 Antibody
Reactivity
Human, Mouse, Rat
Applications
Immunohistochemistry, Western Blot, ELISA
Purity
Affinity chromatography purified via peptide column
Synonyms
Caspase-12, Antibody; Caspase-12 Antibody; Casp-12; anti-Casp12 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Purity/Purification
Affinity chromatography purified via peptide column
Form/Format
Supplied in PBS containing 0.02% sodium azide.
Sequence Length
419
Applicable Applications for anti-Casp12 antibody
IHC (Immunohistochemistry), WB (Western Blot), ELISA
Immunogen Type
Peptide
Immunogen Description
Raised against a peptide corresponding to amino acids 100 to 116 of murine caspase-12.
Target Name
Caspase-12
Preparation and Storage
Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
IHC (Immunohiostchemistry)
(Immunohistochemical staining of mouse liver tissue using caspase-12 antibody at 2 ug/mL.)
IHC (Immunohiostchemistry)
(Immunohistochemical staining of mouse liver tissue using caspase-12 antibody at 2 ug/mL.)
WB (Western Blot)
(Western blot analysis of caspase-12 in mouse brain tissue lysate in the absence (A) or presence (B) of blocking peptide with caspase-12 antibody (IN) at 1 ug/mL.)
WB (Western Blot)
(Western blot analysis of caspase-12 in mouse brain tissue lysate in the absence (A) or presence (B) of blocking peptide with caspase-12 antibody (IN) at 1 ug/mL.)
Related Product Information for anti-Casp12 antibody
Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the mains, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including gamma-secretase presenilin and beta-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-beta. Caspase-12 is ubiquitously expressed in mouse tissues.
Product Categories/Family for anti-Casp12 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
47,854 Da
NCBI Official Full Name
caspase-12
NCBI Official Synonym Full Names
caspase 12
NCBI Official Symbol
Casp12
NCBI Protein Information
caspase-12
UniProt Protein Name
Caspase-12
UniProt Gene Name
Casp12
UniProt Synonym Gene Names
CASP-12
UniProt Entry Name
CASPC_MOUSE
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Product Notes
The Casp12 casp12 (Catalog #AAA305376) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Caspase-12 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Caspase-12 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), WB (Western Blot), ELISA. Researchers should empirically determine the suitability of the Casp12 casp12 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Caspase-12, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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