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IHC (Immunohistchemistry)
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Rabbit Caveolin-3/CAV3 Polyclonal Antibody | anti-CAV3 antibody

Anti-Caveolin-3/CAV3 Antibody, Rabbit Polyclonal

Gene Names
CAV3; LQT9; VIP21; LGMD1C; VIP-21
Reactivity
Human, Mouse, Rat
Applications
Immunohistochemistry
Purity
Protein A & Antigen Affinity
Synonyms
Caveolin-3/CAV3, Antibody; Anti-Caveolin-3/CAV3 Antibody, Rabbit Polyclonal; CAV3 Antibody, Rabbit PAb, Antigen Affinity Purified; caveolin 3; Anti-LGMD1C Antibody; Anti-LQT9 Antibody; Anti-VIP-21 Antibody; Anti-VIP21 Antibody; anti-CAV3 antibody
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For Research Use Only!
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
Human Caveolin-3/CAV3
Purity/Purification
Protein A & Antigen Affinity
Form/Format
Liquid; 0.2um filtered solution in PBS
Applicable Applications for anti-CAV3 antibody
Immunohistochemistry-Paraffin (IHC-P)
Application Notes
IHC-P: 1:1000-1:5000
Immunogen
A synthetic peptide corresponding to the N-terminus of the Human CAV3
Conjugation
Unconjugated
Preparation
Produced in rabbits immunized with A synthetic peptide corresponding to the N-terminus of the Human CAV3, and purified by antigen affinity chromatography.
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.

IHC (Immunohistchemistry)

(Immunochemical staining CAV3 in rat skeletal muscle with rabbit polyclonal antibody at 1:2000 dilution, formalin-fixed paraffin embedded sections.)

IHC (Immunohistochemistry)

(Immunochemical staining CAV3 in rat heart with rabbit polyclonal antibody at 1:2000 dilution, formalin-fixed paraffin embedded sections.)

IHC (Immunohistochemistry)

(Immunochemical staining CAV3 in mouse skeletal muscle with rabbit polyclonal antibody at 1:2000 dilution, formalin-fixed paraffin embedded sections.)

IHC (Immunohistochemistry)

(Immunochemical staining CAV3 in mouse heart with rabbit polyclonal antibody at 1:2000 dilution, formalin-fixed paraffin embedded sections.)

IHC (Immunohistochemistry)

(Immunochemical staining CAV3 in human heart with rabbit polyclonal antibody (1:2000, formalin-fixed paraffin embedded sections))

IHC (Immunohistochemistry)

(Immunochemical staining CAV3 in human skeletal muscle with rabbit polyclonal antibody (1:2000, formalin-fixed paraffin embedded sections).)

Related Product Information for anti-CAV3 antibody
Caveolinopathies are a heterogeneous family of genetic pathologies arising from alterations of the caveolin-3 gene (CAV3), encoding for the isoform specifically constituting muscle caveolae. Caveolin-3 (CAV3) is a principal structural protein of the caveolae membrane domains, which has been reported to participate in cell signaling as well as the maintenance of cell structure. Mutations in the CAV3 gene encoding caveolin-3 (Cav3), a scaffolding protein integral to caveolae in cardiomyocytes, have been associated with the congenital long-QT syndrome (LQT9). Mutations in caveolin-3 (CAV3) can lead to different clinical phenotypes affecting skeletal or cardiac muscles. Mutations in CAV3 lead to various neuromuscular phenotypes with partial overlap, including limb-girdle muscular dystrophy type 1C (LGMD1C), rippling muscle disease, distal myopathy, and isolated hyperCKemia.
References
Yang RB, et al. (2019) Overexpression of cav3 facilitates bone formation via the wnt signaling pathway in osteoporotic rats. Endocrine 63 (3): 639-650.Tyan L, et al. (2019) Long qt syndrome caveolin-3 mutations differentially modulate k(v) 4 and ca(v) 1.2 channels to contribute to action potential prolongation. J Physiol 597 (6): 1531-1551.Stavusis J, et al. (2015) Cav3 gene sequence variations: National genome database and clinics. Acta Neurol Scand 132 (3): 185-190.Scalco RS, et al. (2016) Cav3 mutations causing exercise intolerance, myalgia and rhabdomyolysis: Expanding the phenotypic spectrum of caveolinopathies. Neuromuscul Disord 26 (8): 504-510.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
859
UniProt Accession #
Molecular Weight
17,259 Da
NCBI Official Full Name
Caveolin-3
NCBI Official Synonym Full Names
caveolin 3
NCBI Official Symbol
CAV3
NCBI Official Synonym Symbols
LQT9; VIP21; LGMD1C; VIP-21
NCBI Protein Information
caveolin-3; M-caveolin
UniProt Protein Name
Caveolin-3
UniProt Gene Name
CAV3
UniProt Entry Name
CAV3_HUMAN

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Product Notes

The CAV3 cav3 (Catalog #AAA27716) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-Caveolin-3/CAV3 Antibody, Rabbit Polyclonal reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Caveolin-3/CAV3 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry-Paraffin (IHC-P). IHC-P: 1:1000-1:5000. Researchers should empirically determine the suitability of the CAV3 cav3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Caveolin-3/CAV3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.