IF (Immunofluorescence)
(Immunofluorescence of cbl in human lymph node tissue with cbl antibody at 20 μg/mL.)
Rabbit Cbl Polyclonal Antibody | anti-CBL antibody
Cbl Antibody
Gene Names
CBL; CBL2; NSLL; C-CBL; RNF55; FRA11B
Reactivity
Human, Mouse, Rat
Applications
Immunofluorescence, Western Blot, ELISA
Purity
Cbl Antibody is affinity chromatography purified via peptide column.
Synonyms
Cbl, Antibody; Cbl Antibody; Cbl; CBL2; NSLL; C-CBL; RNF55; FRA11B; E3 ubiquitin-protein ligase CBL; Casitas B-lineage lymphoma proto-oncogene; Cas-Br-M (murine) ecotropic retroviral transforming sequence; anti-CBL antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Cbl Antibody is affinity chromatography purified via peptide column.
Form/Format
Liquid
Concentration
1 mg/mL (varies by lot)
Sequence Length
906
Applicable Applications for anti-CBL antibody
IF (Immunofluorescence), WB (Western Blot), ELISA
Conjugate
Unconjugated
Immunogen
Cbl antibody was raised against a 14 amino acid synthetic peptide from near the carboxy terminus of human cbl.
Buffer
Cbl Antibody is supplied in PBS containing 0.02% sodium azide.
Preparation and Storage
Cbl antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
IF (Immunofluorescence)
(Immunofluorescence of cbl in human lymph node tissue with cbl antibody at 20 μg/mL.)
IF (Immunofluorescence)
(Immunofluorescence of cbl in human lymph node tissue with cbl antibody at 20 μg/mL.)
WB (Western Blot)
(Western blot analysis of cbl in Daudi cell lysate with cbl antibody at (A) 0.5, (B) 1, and (C) 2 μg/mL.)
WB (Western Blot)
(Western blot analysis of cbl in Daudi cell lysate with cbl antibody at (A) 0.5, (B) 1, and (C) 2 μg/mL.)
Related Product Information for anti-CBL antibody
Cbl Antibody: The mammalian cbl family of ubiquitin ligases consists of three homologs known as cbl (also known as c-Cbl), Cbl-B, and Cbl-3 which share highly conserved a tyrosine-kinase-binding domain, linker and RING finger domain in their amino-terminal halves. Similar to other E3 ubiquitin ligases, Cbl catalyzes the transfer of ubiquitin from an E2 or Ubc (ubiquitin-conjugating) enzyme to the e-amino group of a lysine residue of the substrate protein. Cbl acts to negatively regulate many types of cell-surface receptors, including the Syk protein tyrosine kinase family. Cbl is thought to be involved in T- and B-cell signaling, in addition to thymus development. Of the three known homologs in the cbl family, cbl antibody reacts specifically with cbl. Multiple isoforms of cbl have been reported.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
99,633 Da
NCBI Official Full Name
E3 ubiquitin-protein ligase CBL
NCBI Official Synonym Full Names
Cbl proto-oncogene, E3 ubiquitin protein ligase
NCBI Official Symbol
CBL
NCBI Official Synonym Symbols
CBL2; NSLL; C-CBL; RNF55; FRA11B
NCBI Protein Information
E3 ubiquitin-protein ligase CBL; oncogene CBL2; proto-oncogene c-Cbl; RING finger protein 55; signal transduction protein CBL; casitas B-lineage lymphoma proto-oncogene; fragile site, folic acid type, rare, fra(11)(q23.3); Cas-Br-M (murine) ecotropic retroviral transforming sequence
UniProt Protein Name
E3 ubiquitin-protein ligase CBL
UniProt Gene Name
CBL
UniProt Synonym Gene Names
CBL2; RNF55
UniProt Entry Name
CBL_HUMAN
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Product Notes
The CBL cbl (Catalog #AAA39465) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Cbl Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Cbl can be used in a range of immunoassay formats including, but not limited to, IF (Immunofluorescence), WB (Western Blot), ELISA. Researchers should empirically determine the suitability of the CBL cbl for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Cbl, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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