IHC (Immunohiostchemistry)
(Immunohistochemistry of CCDC98 in human breast tissue with CCDC98 antibody at 5 ug/mL.)
Rabbit anti-Human, Mouse CCDC98 Polyclonal Antibody | anti-CCDC98 antibody
CCDC98 Antibody
Gene Names
FAM175A; ABRA1; CCDC98
Reactivity
Human, Mouse
Applications
Immunohistochemistry, Western Blot, ELISA
Purity
Affinity chromatography purified via peptide column
Synonyms
CCDC98, Antibody; CCDC98 Antibody; Coiled-coil domain 98, Abraxas 1, ABRA1; anti-CCDC98 antibody
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Purity/Purification
Affinity chromatography purified via peptide column
Form/Format
Supplied in PBS containing 0.02% sodium azide.
Sequence Length
409
Applicable Applications for anti-CCDC98 antibody
IHC (Immunohistochemistry), WB (Western Blot), ELISA
Immunogen Type
Peptide
Immunogen Description
Raised against a 15 amino acid peptide from near the amino terminus of human CCDC98.
Target Name
CCDC98
Preparation and Storage
Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
IHC (Immunohiostchemistry)
(Immunohistochemistry of CCDC98 in human breast tissue with CCDC98 antibody at 5 ug/mL.)
IHC (Immunohiostchemistry)
(Immunohistochemistry of CCDC98 in human breast tissue with CCDC98 antibody at 5 ug/mL.)
WB (Western Blot)
(Western blot analysis of CCDC98 in human breast tissue lysate in (A) the absence and (B) presence of blocking peptide with CCDC98 antibody at 1 ug/mL.)
WB (Western Blot)
(Western blot analysis of CCDC98 in human breast tissue lysate in (A) the absence and (B) presence of blocking peptide with CCDC98 antibody at 1 ug/mL.)
Related Product Information for anti-CCDC98 antibody
CCDC98, also known as Abraxas 1, was identified through protein binding studies using the breast and ovarian predisposition protein BRCA1 as the binding target. CCDC98 recruits RAP80, a ubiquitin-binding protein, to BRCA1, allowing the formation of BRCA1 foci in response to DNA damage caused by ionizing radiation. Both CCDC98 and RAP80 are required for DNA damage resistance, G2-M checkpoint control, and DNA repair. Cells depleted of either CCDC98 or RAP80 exhibited increased sensitivity to ionizing radiation, although not as much as in BRCA1-depleted cells, suggesting that CCDC98 and RAP80 control only part of the DNA damage response role of BRCA1. At least two isoforms of CCDC98 are known to exist.
Product Categories/Family for anti-CCDC98 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
46,663 Da
NCBI Official Full Name
BRCA1-A complex subunit Abraxas
NCBI Official Synonym Full Names
family with sequence similarity 175, member A
NCBI Official Symbol
FAM175A
NCBI Official Synonym Symbols
ABRA1; CCDC98
NCBI Protein Information
BRCA1-A complex subunit Abraxas
UniProt Protein Name
BRCA1-A complex subunit Abraxas
UniProt Gene Name
FAM175A
UniProt Synonym Gene Names
ABRA1; CCDC98
UniProt Entry Name
F175A_HUMAN
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Product Notes
The CCDC98 fam175a (Catalog #AAA301378) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CCDC98 Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's CCDC98 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), WB (Western Blot), ELISA. Researchers should empirically determine the suitability of the CCDC98 fam175a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CCDC98, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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