Rabbit anti-Mouse, Rat CD193 Polyclonal Antibody | anti-CD193 antibody

RABBIT ANTI HUMAN CD193

Cat. Num. AAA49912

• Gene Names: CCR3; CKR3; CD193; CMKBR3; CC-CKR-3
• Reactivity: Mouse, Rat
• Applications: Western Blot, Immunohistochemistry, Immunofluorescence, Immunohistochemistry
• Synonyms: CD193, Antibody; RABBIT ANTI HUMAN CD193; anti-CD193 antibody

• Host: Rabbit
• Reactivity: Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Form/Format: Purified; Purified IgG - liquid
• Concentration: IgG concentration 0.5mg/ml (varies by lot)
• Sequence Length: 376

• Applicable Applications for anti-CD193 antibody: WB (Western Blot), IHC (Immunohistochemistry), IF (Immunofluorescence), IHC (Immunohistochemistry)
• Perservative Stabilisers: 0.02% Sodium Azide (NaN3)
• Histology Positive Control Tissue: Human spleen.; Buffer Solution
• Antiserum Preparation: Antisera to human CD193 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
• Target Species: Human
• Preparation and Storage: Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.; Shelf Life: 18 months from date of despatch.

Application Data

(Formalin fixed, paraffin embedded normal human spleen stained with Rabbit anti Human CD193 (AAA49912) following heat mediated antigen retrieval using sodium citrate buffer (pH6.0))

Application Data

(Western blot analysis on normal human spleen lysate probed with Rabbit anti Human CD193 (AAA49912))

Related Product Information for anti-CD193 antibody

Rabbit anti Human CD193 antibody recognizes human CD193, otherwise known as CC chemokine receptor 3 (CCR3), a seven-helix transmembrane G-protein coupled receptor which, along with CCR5 and CXCR4, acts as a principal receptor for the fusion and entry of HIV into target cells. CD193 is expressed by eosinophils, basophils, mast cells, microglia, Th2 helper cells and some epithelial cells. CD193 acts as a receptor for several CC chemokines including monocyte chemoattractant proteins (MCP) -1, -2, -3 and -4, MIP-1a, MIP-1beta, and RANTES. The eotaxin subgroup of CC chemokines act as specific agonists for CD193, and this interaction has become a focus area for studies into the infection of microglia by HIV (He, J. et al. 1997) and allergy research (Holse, M. et al. 2006). Rabbit anti Human CD193 antibody has been used successfully for the detection of human CD193 by immunohistochemistry on formalin fixed, paraffin embedded intervertebral disc tissue (Gruber et al. 2014).

NCBI and Uniprot Product Information

• NCBI GI #: 4502637
• NCBI GeneID: 1232
• NCBI Accession #: NP_001828.1
• NCBI GenBank Nucleotide #: NM_001837.3
• UniProt Accession #: P51677; Q15748; Q2YDB9; Q86WD2; Q8TDP6; Q9ULY8; B3KVQ1; F5GWL6
• Molecular Weight: 43,453 Da
• NCBI Official Full Name: C-C chemokine receptor type 3 isoform 1
• NCBI Official Synonym Full Names: chemokine (C-C motif) receptor 3
• NCBI Official Symbol: CCR3
• NCBI Official Synonym Symbols: CKR3; CD193; CMKBR3; CC-CKR-3
• NCBI Protein Information: C-C chemokine receptor type 3; C-C CKR-3; CC chemokine receptor 3; CCR-3; b-chemokine receptor; eosinophil CC chemokine receptor 3; eosinophil eotaxin receptor
• UniProt Protein Name: C-C chemokine receptor type 3
• UniProt Gene Name: CCR3
• UniProt Synonym Gene Names: CMKBR3; C-C CKR-3; CC-CKR-3; CCR-3; CCR3; CKR3
• UniProt Entry Name: CCR3_HUMAN