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IHC (Immunohistochemistry)
(CD63 Antibody-Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE))
Rabbit CD63 Polyclonal Antibody | anti-CD63 antibody
CD63 Rabbit anti-Human Polyclonal Antibody
Gene Names
CD63; MLA1; ME491; LAMP-3; OMA81H; TSPAN30
Reactivity
Mouse, Rat, Human
Applications
Western Blot, Immunohistochemistry
Purity
Immunoaffinity chromatography
Synonyms
CD63, Antibody; CD63 Rabbit anti-Human Polyclonal Antibody; PathPlus CD63 Antibody; CD63; CD63 molecule; LAMP-3; ME491; Granulophysin; MLA1; Tetraspanin-30; Tspan-30; CD63 antigen; OMA81H; TSPAN30; anti-CD63 antibody
Host
Rabbit
Reactivity
Mouse, Rat, Human
Clonality
Polyclonal
Specificity
Recognizes endogenous levels of CD63 protein.
Purity/Purification
Immunoaffinity chromatography
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH7.3, 30% glycerol, and 0.01% sodium azide.
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-CD63 antibody
WB (Western Blot), IHC (Immunohistochemistry)
Target
Human CD63
Immunogen
Recombinant full length protein of human CD63
Conjugation
Unconjugated
Family
Tetraspan
Preparation and Storage
Aliquot and store at -20 degree C for 1 year. Avoid freeze/thaw cycles.
IHC (Immunohistochemistry)
(CD63 Antibody-Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohistochemistry)
(CD63 Antibody-Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohistochemistry)
(CD63 Antibody-Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohistochemistry)
(CD63 Antibody-Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohistochemisry)
(CD63 Antibody-Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohistochemisry)
(CD63 Antibody-Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohiostchemistry)
(CD63 Antibody-Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohiostchemistry)
(CD63 Antibody-Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE))
WB (Western Blot)
(CD63 Antibody)
WB (Western Blot)
(CD63 Antibody)
Related Product Information for anti-CD63 antibody
CD63 antibody is an unconjugated rabbit polyclonal antibody to CD63 from human. It is reactive with human, mouse and rat. Validated for IHC and WB.
CD63 (CD63 antigen, LAMP-3, NKI-C3, ME491, melanoma associated antigen CD63) is a member of the tetraspanin integral membrane glycoprotein family that plays a role in intracellular vesicular transport and is involved in cell morphology, motility, and proliferation. CD63 is mainly associated with intracellular vesicles (eg, lysosomes and endosomes) but can be expressed at the cell surface and secreted as exosomes through fusion of endosomes with the plasma membrane. It is broadly expressed in the body, including within gastric parietal cells, platelets, endothelial cells, fibroblasts, mast cells, brain white matter, renal tubules, macrophages, dendritic cells, T-lymphocytes, neutrophils, and many epithelial cells. CD63 is also associated with tumor progression, where the protein is overexpressed during the early stages and reduced as invasion and malignancy progresses (melanomas, ovarian cancers, lung, breast and colon carcinomas). Antibodies to CD63 can be used to identify melanoma and melanocytic tumors and other tumors.
CD63 (CD63 antigen, LAMP-3, NKI-C3, ME491, melanoma associated antigen CD63) is a member of the tetraspanin integral membrane glycoprotein family that plays a role in intracellular vesicular transport and is involved in cell morphology, motility, and proliferation. CD63 is mainly associated with intracellular vesicles (eg, lysosomes and endosomes) but can be expressed at the cell surface and secreted as exosomes through fusion of endosomes with the plasma membrane. It is broadly expressed in the body, including within gastric parietal cells, platelets, endothelial cells, fibroblasts, mast cells, brain white matter, renal tubules, macrophages, dendritic cells, T-lymphocytes, neutrophils, and many epithelial cells. CD63 is also associated with tumor progression, where the protein is overexpressed during the early stages and reduced as invasion and malignancy progresses (melanomas, ovarian cancers, lung, breast and colon carcinomas). Antibodies to CD63 can be used to identify melanoma and melanocytic tumors and other tumors.
References
Exp Cell Res 2009: 1484-1592; Thromb Res. 2010;125(2):152-158. doi: 10.1016/j.thromres.2009.07.005; Cytometry A. 2004;61(1):62-68. doi: 10.1002/cyto.a.20068; Dev Cell. 2011;21(4):708-721. doi: 10.1016/j.devcel.2011.08.019; Cancer Res. 1988;48(11):2955-2962. PMID: 3365686; Am J Pathol. 1998;153(3):973-983. PMID: 9736046; Arch Pathol Lab Med. 2001;125(6):751-758. doi: 10.1043/0003-9985(2001)125<0751:RA>2.0.CO;2.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
17,271 Da
NCBI Official Full Name
CD63 antigen isoform A
NCBI Official Synonym Full Names
CD63 molecule
NCBI Official Symbol
CD63
NCBI Official Synonym Symbols
MLA1; ME491; LAMP-3; OMA81H; TSPAN30
NCBI Protein Information
CD63 antigen; tspan-30; granulophysin; tetraspanin-30; melanoma-associated antigen MLA1; CD63 antigen (melanoma 1 antigen); melanoma-associated antigen ME491; ocular melanoma-associated antigen; lysosomal-associated membrane protein 3; lysosome-associated
UniProt Protein Name
CD63 antigen
UniProt Gene Name
CD63
UniProt Synonym Gene Names
MLA1; TSPAN30; LAMP-3; Tspan-30
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Product Notes
The CD63 cd63 (Catalog #AAA163117) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CD63 Rabbit anti-Human Polyclonal Antibody reacts with Mouse, Rat, Human and may cross-react with other species as described in the data sheet. AAA Biotech's CD63 can be used in a range of immunoassay formats including, but not limited to, WB (Western Blot), IHC (Immunohistochemistry). Researchers should empirically determine the suitability of the CD63 cd63 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD63, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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