WB (Western Blot)
(Western blot analysis of extracts from Colo cells using CDK7 antibody. The lane on the left is treated with synthesized peptide.)
Rabbit anti-Human, Mouse CDK7 Polyclonal Antibody | anti-CDK7 antibody
CDK7 Antibody
Gene Names
CDK7; CAK1; HCAK; MO15; STK1; CDKN7; p39MO15
Reactivity
Human, Mouse
Applications
Immunohistochemistry, Western Blot
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Synonyms
CDK7, Antibody; CDK7 Antibody; 39 kDa protein kinase; CAK; CAK1; CDK-activating kinase; CDKN7; anti-CDK7 antibody
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Specificity
The antibody detects endogenous levels of total CDK7 protein.
Purity/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1.0 mg/ml (varies by lot)
Sequence Length
346
Applicable Applications for anti-CDK7 antibody
IHC (Immunohistochemistry), WB (Western Blot)
Immunogen Type
Peptide
Immunogen Description
Synthesized peptide derived from Internal of human CDK7.
Target Name
CDK7
Preparation and Storage
Store at -20 degree C
WB (Western Blot)
(Western blot analysis of extracts from Colo cells using CDK7 antibody. The lane on the left is treated with synthesized peptide.)
WB (Western Blot)
(Western blot analysis of extracts from Colo cells using CDK7 antibody. The lane on the left is treated with synthesized peptide.)
WB (Western Blot)
(Western blot analysis of extracts from 293 cells, using CDK7 antibody.)
WB (Western Blot)
(Western blot analysis of extracts from 293 cells, using CDK7 antibody.)
IHC (Immunohistochemistry)
(Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue using CDK7 antibody.)
IHC (Immunohistochemistry)
(Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue using CDK7 antibody.)
Related Product Information for anti-CDK7 antibody
Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle. Each different complex controls a specific transition between 2 subsequent phases in the cell cycle. Required for both activation and complex formation of CDK1/cyclin-B during G2-M transition, and for activation of CDK2/cyclins during G1-S transition (but not complex formation). CDK7 is the catalytic subunit of the CDK-activating kinase (CAK) complex. Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation, thus regulating cell cycle progression. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Phosphorylation of POLR2A in complex with DNA promotes transcription initiation by triggering dissociation from DNA. Its expression and activity are constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 activation by phosphorylation, but is inactivated in turn by p53/TP53; this feedback loop may lead to an arrest of the cell cycle and of the transcription, helping in cell recovery, or to apoptosis. Required for DNA-bound peptides-mediated transcription and cellular growth inhibition.J. Matt Kim, Biol Reprod, May 2001; 64: 1400. Achim von Leoprechting, Cancer Res., Mar 1999; 59: 1287 - 1294. John J. Long, Mol. Cell. Biol., Mar 1998; 18: 1467 - 1476. Eiji Nishiwaki, Mol. Cell. Biol., Oct 2000; 20: 7726 - 7734.
Product Categories/Family for anti-CDK7 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
39,038 Da
NCBI Official Full Name
cyclin-dependent kinase 7
NCBI Official Synonym Full Names
cyclin-dependent kinase 7
NCBI Official Symbol
CDK7
NCBI Official Synonym Symbols
CAK1; HCAK; MO15; STK1; CDKN7; p39MO15
NCBI Protein Information
cyclin-dependent kinase 7
UniProt Protein Name
Cyclin-dependent kinase 7
UniProt Gene Name
CDK7
UniProt Synonym Gene Names
CAK; CAK1; CDKN7; MO15; STK1; p39 Mo15
UniProt Entry Name
CDK7_HUMAN
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Product Notes
The CDK7 cdk7 (Catalog #AAA307680) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CDK7 Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's CDK7 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), WB (Western Blot). Researchers should empirically determine the suitability of the CDK7 cdk7 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CDK7, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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