WB (Western Blot)
(Western blot analysis of extracts from Jurkat cells using CHK2 (Phospho-Thr387) antibody)
Rabbit CHK2 Polyclonal Antibody | anti-CHK2 antibody
CHK2 Antibody (Thr387)
Gene Names
CHEK2; CDS1; CHK2; LFS2; RAD53; hCds1; HuCds1; PP1425
Applications
ELISA, Immunohistochemistry, Western Blot
Purity
Affinity Chromatography
Synonyms
CHK2, Antibody; CHK2 Antibody (Thr387); Rabbit Polyclonal CHK2 Antibody (Thr387); Polyclonal CHK2 antibody; Anti-CHK2 antibody; Cds1 antibody; checkpoint-like protein CHK2 antibody; CHEK2 antibody; CHK2 antibody; CHK2 checkpoint homolog (S. pombe) antibody; HuCds1 antibody; LFS2 antibody; PP1425 antibody; protein kinase CHK2 antibody; RAD53 antibody; Serine/threonine-protein kinase Chk2 antibody; anti-CHK2 antibody
Host
Rabbit
Clonality
Polyclonal
Isotype
IgG
Specificity
CHK2 antibody (Thr387) detects endogenous levels of CHK2 only when phosphorylated at serine 317
Purity/Purification
Affinity Chromatography
Form/Format
Supplied in PBS buffer (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% Sodium Azide and 50% Glycerol
Concentration
1 mg/ml (varies by lot)
Sequence Length
514
Applicable Applications for anti-CHK2 antibody
ELISA, IHC (Immunohistochemistry), WB (Western Blot)
Immunogen
CHK2 antibody was raised in Rabbit using a synthesized phosphopeptide derived from human CHK2 around the phosphorylation site of threonine 387 (C-G-TP-P-T) as the immunogen.
Cross-Reactivity
Mouse, Rat
Preparation and Storage
Store at -20 degree C in small aliquots. Avoid repeat freeze/thaw cycles.
WB (Western Blot)
(Western blot analysis of extracts from Jurkat cells using CHK2 (Phospho-Thr387) antibody)
WB (Western Blot)
(Western blot analysis of extracts from Jurkat cells using CHK2 (Phospho-Thr387) antibody)
IHC (Immunohistochemistry)
(Immunohistochemical analysis of paraffin-embedded human lung adenocarcinoma tissue using CHK2 antibody (Thr387))
IHC (Immunohistochemistry)
(Immunohistochemical analysis of paraffin-embedded human lung adenocarcinoma tissue using CHK2 antibody (Thr387))
Related Product Information for anti-CHK2 antibody
CHK2 phosphorylates numerous effectors preferentially at the consensus sequence [L-X-R-X-X-S/T]. Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their activity. Inhibition of CDC25 phosphatase activity leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. May also phosphorylate NEK6 which is involved in G2/M cell cycle arrest.
Product Categories/Family for anti-CHK2 antibody
NCBI and Uniprot Product Information
Similar Products
Product Notes
The CHK2 (Catalog #AAA226137) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's CHK2 can be used in a range of immunoassay formats including, but not limited to, ELISA, IHC (Immunohistochemistry), WB (Western Blot). Researchers should empirically determine the suitability of the CHK2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CHK2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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