Rabbit CHRNG Polyclonal Antibody | anti-CHRNG antibody

CHRNG Rabbit pAb

Cat. Num. AAA268627

• Gene Names: CHRNG; ACHRG
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot
• Purity: Affinity Purified
• Synonyms: CHRNG, Antibody; CHRNG Rabbit pAb; ACHRG; anti-CHRNG antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: ACHG Polyclonal Antibody detects endogenous levels of protein.
• Purity/Purification: Affinity Purified
• Form/Format: Liquid in PBS with 0.02% sodium azide, 50% glycerol, pH 7.3
• Sequence Length: 517

• Applicable Applications for anti-CHRNG antibody: ELISA, WB (Western Blot)
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 328-517 of human CHRNG (NP_005190.4).
• Organism: Human, Mouse, Rat
• Cellular Localization: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
• Tissue specificity: Muscle fibroblast,PCR rescued clones,Tongue
• Function: Disease:Defects in CHRNG are a cause of Escobar syndrome [MIM:265000]; also called Escobar variant multiple pterygium syndrome or nonlethal type multiple pterygium syndrome. Escobar syndrome is a nonlethal form of arthrogryposis multiplex congenita. It is an autosomal recessive condition characterized by excessive webbing (pterygia), congenital contractures (arthrogryposis), and scoliosis. Variable other features include intrauterine death, congenital respiratory distress, short stature, faciocranial dysmorphism, ptosis, low set ears, arachnodactyly and cryptorchism in males. Congenital contractures are common and may be caused by reduced fetal movements at sensitive times of development. Possible causes of decreased fetal mobility include space constraints such as oligohydramnion, drugs, metabolic conditions or neuromuscular disorders including myasthenia gravis.,Disease:Defects in CHRNG are a cause of lethal type multiple pterygium syndrome [MIM:253290]. Multiple pterygia are found infrequently in children with arthrogryposis and in fetuses with fetal akinesia syndrome. Inheritance can be autosomal dominant, autosomal recessive, or X linked, but autosomal recessive inheritance appears to be most common. Clinical expression is very variable, and, in the severest form, lethal multiple pterygium syndrome there is intrauterine growth retardation, multiple pterygia (e.g., chin to sternum, cervical, axillary, humero-ulnar, crural, popliteal, and ankles), and flexion contractures causing severe arthrogryposis and fetal akinesia.
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

NCBI and Uniprot Product Information

• NCBI GI #: 61743914
• NCBI GeneID: 1146
• NCBI Accession #: NP_005190.4
• NCBI GenBank Nucleotide #: NP_005190.4
• UniProt Accession #: P07510
• Molecular Weight: MW:60kD; Observed band:56kD
• NCBI Official Full Name: acetylcholine receptor subunit gamma
• NCBI Official Synonym Full Names: cholinergic receptor nicotinic gamma subunit
• NCBI Official Symbol: CHRNG
• NCBI Official Synonym Symbols: ACHRG
• NCBI Protein Information: acetylcholine receptor subunit gamma
• UniProt Protein Name: Acetylcholine receptor subunit gamma
• UniProt Gene Name: CHRNG
• UniProt Synonym Gene Names: ACHRG
• UniProt Entry Name: ACHG_HUMAN