Rabbit CIITA Polyclonal Antibody | anti-CIITA antibody

CIITA Antibody

Cat. Num. AAA40260

• Gene Names: CIITA; C2TA; NLRA; MHC2TA; CIITAIV
• Reactivity: Human, Mouse, Rat
• Applications: Immunofluorescence, Immunohistochemistry, Western Blot, ELISA
• Purity: CIITA Antibody is affinity chromatography purified via peptide column.
• Synonyms: CIITA, Antibody; CIITA Antibody; CIITA; C2TA; NLRA; MHC2TA; CIITAIV; MHC class II transactivator; class II, major histocompatibility complex, transactivator; anti-CIITA antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: CIITA Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 1130

• Applicable Applications for anti-CIITA antibody: IF (Immunofluorescence), IHC (Immunohistochemistry), WB (Western Blot), ELISA
• Conjugate: Unconjugated
• Immunogen: CIITA antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human CIITA.
• Buffer: CIITA Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: Antibody can be stored at 4°C up to one year. Antibodies should not be exposed to prolonged high temperatures.

IF (Immunofluorescence)

(Immunofluorescence of CIITA in human brain tissue with CIITA antibody at 20 μg/mL.)

IHC (Immunohiostchemistry)

(Immunohistochemistry of CIITA in human brain tissue with CIITA antibody at 10 μg/mL.)

WB (Western Blot)

(Western blot analysis of CIITA in rat brain tissue lysate with CIITA antibody at 1 μg/mL.)

Related Product Information for anti-CIITA antibody

CIITA Antibody: CIITA contains an acidic transcriptional activation domain, four LRRs (leucine-rich repeats) and a GTP binding domain. It is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the "master control factor" for the expression of these genes. CIITA also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction.

NCBI and Uniprot Product Information

• NCBI GI #: 218511957
• NCBI GeneID: 4261
• UniProt Accession #: P33076; Q29675; Q8SNB8; Q96KL4; A0N0N9; D3DUG0; E9PFE0
• Molecular Weight: Predicted: 124 kDa; ; Observed: 125 kDa
• NCBI Official Full Name: MHC class II transactivator
• NCBI Official Synonym Full Names: class II, major histocompatibility complex, transactivator
• NCBI Official Symbol: CIITA
• NCBI Official Synonym Symbols: C2TA; NLRA; MHC2TA; CIITAIV
• NCBI Protein Information: MHC class II transactivator; NLR family, acid domain containing; MHC class II transactivator type III; nucleotide-binding oligomerization domain, leucine rich repeat and acid domain containing
• UniProt Protein Name: MHC class II transactivator
• UniProt Gene Name: CIITA
• UniProt Synonym Gene Names: MHC2TA; CIITA
• UniProt Entry Name: C2TA_HUMAN