WB (Western Blot)
(Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.)
Rabbit anti-Human Cleaved-Caspase-4 p20 Polyclonal Antibody | anti-CASP4 antibody
Cleaved-Caspase-4 p20 (Q81) Polyclonal Antibody
Gene Names
CASP4; TX; ICH-2; Mih1/TX; ICEREL-II; ICE(rel)II
Reactivity
Human
Applications
Immunohistochemistry, Western Blot
Synonyms
Cleaved-Caspase-4 p20, Antibody; Cleaved-Caspase-4 p20 (Q81) Polyclonal Antibody; CASP4; ICH2; Caspase-4; CASP-4; ICE (rel)-II; Protease ICH-2; Protease TX; anti-CASP4 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Applicable Applications for anti-CASP4 antibody
IHC (Immunohistochemistry), WB (Western Blot)
Notes
ECO:0000303|PubMed:15123740, ECO:0000312|HGNC: HGNC:1505
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 2 weeks. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
WB (Western Blot)
(Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.)
WB (Western Blot)
(Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.)
WB (Western Blot)
(Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.)
WB (Western Blot)
(Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.)
Related Product Information for anti-CASP4 antibody
Inflammatory caspase (PubMed:23516580, PubMed:25119034). Essential effector of NLRP3 inflammasome- dependent CASP1 activation and IL1B and IL18 secretion in response to non-canonical activators, such as UVB radiation, cholera enterotoxin subunit B and cytosolic LPS (PubMed:26174085, PubMed:26173988, PubMed:26508369, PubMed:25964352). Independently of NLRP3 inflammasome and CASP1, promotes pyroptosis, through GSDMD cleavage and activation, and IL1A, IL18 and HMGB1 release in response to non-canonical inflammasome activators (PubMed:25964352). Plays a crucial role in the restriction of Salmonella typhimurium replication in colonic epithelial cells during infection (PubMed:22246630, PubMed:23661706). Activated by direct binding to LPS without the need of an upstream sensor (PubMed:7797592, PubMed:7797510). During non- canonical inflammasome activation, cuts CGAS and may play a role in the regulation of antiviral innate immune activation (PubMed:28314590).
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
43,262 Da
NCBI Official Full Name
caspase-4 isoform alpha
NCBI Official Synonym Full Names
caspase 4, apoptosis-related cysteine peptidase
NCBI Official Symbol
CASP4
NCBI Official Synonym Symbols
TX; ICH-2; Mih1/TX; ICEREL-II; ICE(rel)II
NCBI Protein Information
caspase-4; CASP-4; ICE(rel)-II; protease TX; protease ICH-2; apoptotic cysteine protease Mih1/TX; caspase 4, apoptosis-related cysteine protease
UniProt Protein Name
Caspase-4
UniProt Gene Name
CASP4
UniProt Synonym Gene Names
ICH2; CASP-4
UniProt Entry Name
CASP4_HUMAN
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Product Notes
The CASP4 casp4 (Catalog #AAA293426) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Cleaved-Caspase-4 p20 (Q81) Polyclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Cleaved-Caspase-4 p20 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), WB (Western Blot). Researchers should empirically determine the suitability of the CASP4 casp4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Cleaved-Caspase-4 p20, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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