Application Data
(Zhang, Daoming, et al. "Ginsenoside Rg5 induces apoptosis in human esophageal cancer cells through the phosphoinositide?3 kinase/protein kinase B signaling pathway." Molecular medicine reports 19.5 (2019): 4019-4026.)
Rabbit Cleaved-Caspase-8 p18 Polyclonal Antibody | anti-CASP8 antibody
Cleaved-Caspase-8 p18 (S217) Rabbit Polyclonal Antibody
Gene Names
CASP8; CAP4; MACH; MCH5; FLICE; ALPS2B; Casp-8
Reactivity
Human, Rat, Mouse
Applications
ELISA, Western Blot
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Synonyms
Cleaved-Caspase-8 p18, Antibody; Cleaved-Caspase-8 p18 (S217) Rabbit Polyclonal Antibody; CASP8; MCH5; Caspase-8; CASP-8; Apoptotic cysteine protease; Apoptotic protease Mch-5; CAP4; FADD-homologous ICE/ced-3-like protease; FADD-like ICE; FLICE; ICE-like apoptotic protease 5; MORT1-associated ced-3 homolog; MACH; BH6842; Caspase8; anti-CASP8 antibody
Host
Rabbit
Reactivity
Human, Rat, Mouse
Clonality
Polyclonal
Specificity
Cleaved-Caspase-8 p18 (S217) Polyclonal Antibody detects endogenous levels of Cleaved-Caspase-8 p18 (S217) protein.
Purity/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-CASP8 antibody
ELISA, WB (Western Blot)
Immunogen
Synthesized peptide derived from Cleaved-Caspase-8 p18 (S217). at AA range: 170-250
Modification
Cleaved Specific
Preparation and Storage
Store at -20 degree C/1 year
Application Data
(Zhang, Daoming, et al. "Ginsenoside Rg5 induces apoptosis in human esophageal cancer cells through the phosphoinositide?3 kinase/protein kinase B signaling pathway." Molecular medicine reports 19.5 (2019): 4019-4026.)
Application Data
(Zhang, Daoming, et al. "Ginsenoside Rg5 induces apoptosis in human esophageal cancer cells through the phosphoinositide?3 kinase/protein kinase B signaling pathway." Molecular medicine reports 19.5 (2019): 4019-4026.)
WB (Western Blot)
(Western blot analysis of MOUSE-SPLEEN using Caspase-8 P18 antibody. Antibody was diluted at 1:1000. Secondary antibody was diluted at 1:20000)
WB (Western Blot)
(Western blot analysis of MOUSE-SPLEEN using Caspase-8 P18 antibody. Antibody was diluted at 1:1000. Secondary antibody was diluted at 1:20000)
WB (Western Blot)
(Western blot analysis of MOUSE-SPLEEN using Cleaved-Caspase-8 p18 (S217) antibody. Antibody was diluted at 1:1000. Secondary antibody was diluted at 1:20000)
WB (Western Blot)
(Western blot analysis of MOUSE-SPLEEN using Cleaved-Caspase-8 p18 (S217) antibody. Antibody was diluted at 1:1000. Secondary antibody was diluted at 1:20000)
Related Product Information for anti-CASP8 antibody
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alt
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
55,391 Da
NCBI Official Full Name
caspase-8 isoform C
NCBI Official Synonym Full Names
caspase 8, apoptosis-related cysteine peptidase
NCBI Official Symbol
CASP8
NCBI Official Synonym Symbols
CAP4; MACH; MCH5; FLICE; ALPS2B; Casp-8
NCBI Protein Information
caspase-8; FADD-like ICE; MACH-alpha-1/2/3 protein; apoptotic protease Mch-5; MACH-beta-1/2/3/4 protein; apoptotic cysteine protease; ICE-like apoptotic protease 5; MORT1-associated ced-3 homolog; FADD-homologous ICE/CED-3-like protease; caspase 8, apopto
UniProt Protein Name
Caspase-8
UniProt Gene Name
CASP8
UniProt Synonym Gene Names
MCH5; CASP-8; FLICE; MACH
UniProt Entry Name
CASP8_HUMAN
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Product Notes
The CASP8 casp8 (Catalog #AAA319051) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Cleaved-Caspase-8 p18 (S217) Rabbit Polyclonal Antibody reacts with Human, Rat, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Cleaved-Caspase-8 p18 can be used in a range of immunoassay formats including, but not limited to, ELISA, WB (Western Blot). Researchers should empirically determine the suitability of the CASP8 casp8 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Cleaved-Caspase-8 p18, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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