IHC (Immunohiostchemistry)
(Immunochemical staining of human CLPTM1L in human thyroid cancer with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).)
Rabbit anti-Human CLPTM1L Polyclonal Antibody | anti-CLPTM1L antibody
Anti-CLPTM1L Antibody, Rabbit Polyclonal
Gene Names
CLPTM1L; CRR9
Reactivity
Human
Applications
Immunohistochemistry
Purity
Protein A & Antigen Affinity
Synonyms
CLPTM1L, Antibody; Anti-CLPTM1L Antibody, Rabbit Polyclonal; CLPTM1L Antibody, Rabbit PAb, Antigen Affinity Purified; Anti-CLPTM1L Antibody; Anti-CRR9 Antibody; anti-CLPTM1L antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
Human CLPTM1L
Purity/Purification
Protein A & Antigen Affinity
Form/Format
Liquid; 0.2um filtered solution in PBS
Applicable Applications for anti-CLPTM1L antibody
IHC (Immunohistochemistry)
Immunogen
A synthetic peptide corresponding to the C-terminus of the Human CLPTM1L
Conjugation
Unconjugated
Preparation
Produced in rabbits immunized with a synthetic peptide corresponding to the C-terminus of the Human CLPTM1L, and purified by antigen affinity chromatography.
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.
IHC (Immunohiostchemistry)
(Immunochemical staining of human CLPTM1L in human thyroid cancer with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).)
IHC (Immunohiostchemistry)
(Immunochemical staining of human CLPTM1L in human thyroid cancer with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).)
IHC (Immunohistochemistry)
(Immunochemical staining of human CLPTM1L in human hepatoma with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).)
IHC (Immunohistochemistry)
(Immunochemical staining of human CLPTM1L in human hepatoma with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).)
Related Product Information for anti-CLPTM1L antibody
Cleft Lip and Palate Transmembrane 1-Like (CLPTM1L)/Cisplatin Resistance Related Protein 9 (CRR9), located on chromosome 5p15.33, affects multiple survival signaling pathways in tumor cells under oncogenic, genotoxic, and microenvironmental stress. The transmembrane protein CLPTM1L is overexpressed in non-small cell lung cancer, where it protects tumor cells from genotoxic apoptosis. RNA interference-mediated blockade of CLPTM1L inhibits K-Ras-induced lung tumorigenesis. CLPTM1L interacts with phosphoinositide 3-kinase and is essential for Ras-induced AKT phosphorylation. The anti-apoptotic protein Bcl-xL is regulated by CLPTM1L independently of AKT activation. Constitutive activation of AKT or Bcl-xL rescued the transformed phenotype in CLPTM1L-depleted cells. CLPTM1L is associated with lung cancer and it may be associated with anti-apoptotic mechanism which affects drug-resistance. CLPTM1L plays a protumorigenic role in Ras-driven lung cancers, with potential implications for therapy and chemosensitization.
References
Su LY, et al. (2014) Polymorphisms of tert and clptm1l and the risk of hepatocellular carcinoma in chinese males. Asian Pac J Cancer Prev 15 (19): 8197-8201.Jia J, et al. (2014) Clptm1l promotes growth and enhances aneuploidy in pancreatic cancer cells. Cancer Res 74 (10): 2785-2795.James MA, et al. (2014) Crr9/clptm1l regulates cell survival signaling and is required for ras transformation and lung tumorigenesis. Cancer Res 74 (4): 1116-1127.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
58,356 Da
NCBI Official Full Name
cleft lip and palate transmembrane protein 1-like protein
NCBI Official Synonym Full Names
CLPTM1-like
NCBI Official Symbol
CLPTM1L
NCBI Official Synonym Symbols
CRR9
NCBI Protein Information
cleft lip and palate transmembrane protein 1-like protein; CLPTM1-like protein; CRR9p; cisplatin resistance related protein CRR9p; cisplatin resistance-related protein 9
UniProt Protein Name
Cleft lip and palate transmembrane protein 1-like protein
UniProt Gene Name
CLPTM1L
UniProt Synonym Gene Names
CRR9; CLPTM1-like protein; CRR9p
UniProt Entry Name
CLP1L_HUMAN
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Product Notes
The CLPTM1L clptm1l (Catalog #AAA254883) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-CLPTM1L Antibody, Rabbit Polyclonal reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CLPTM1L can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry). Researchers should empirically determine the suitability of the CLPTM1L clptm1l for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CLPTM1L, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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