Rabbit COL9A1 Polyclonal Antibody | anti-COL9A1 antibody

COL9A1 Polyclonal Antibody

Cat. Num. AAA268834

• Gene Names: COL9A1; MED; EDM6; STL4; DJ149L1.1.2
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Immunohistochemistry, Immunofluorescence, Western Blot
• Purity: Affinity Purification
• Synonyms: COL9A1, Antibody; COL9A1 Polyclonal Antibody; DJ149L1.1.2; EDM6; MED; STL4; anti-COL9A1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: COL9A1 Polyclonal Antibody detects endogenous levels of COL9A1 protein.
• Purity/Purification: Affinity Purification
• Form/Format: PBS with 0.02% sodium azide, 50% glycerol, pH 7.3.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 921

• Applicable Applications for anti-COL9A1 antibody: ELISA, IHC (Immunohistochemistry), IF (Immunofluorescence), WB (Western Blot)
• Immunogen: Synthesized peptide derived from COL9A1 at AA range: 390-470
• Organism: Human,Mouse
• Cellular Localization: Secreted, extracellular space, extracellular matrix
• Tissue specificity: Brain, Mammary gland
• Function: Alternative products:Additional isoforms seem to exist,Disease:Defects in COL9A1 are a cause of COL9A1-related multiple epiphyseal dysplasia (COL9A1-MED) [MIM:120210].,Disease:Defects in COL9A1 are the cause of Stickler syndrome autosomal recessive COL9A1-related (COL9A1ARSTL) [MIM:120210]. COL9A1ARSTL is an autosomal recessive form of Stickler syndrome, an inherited disorder that associates ocular signs with more or less complete forms of Pierre Robin sequence, bone disorders and sensorineural deafness. Ocular disorders may include juvenile cataract, myopia, strabismus, vitreoretinal or chorioretinal degeneration, retinal detachment, and chronic uveitis. Robin sequence includes an opening in the roof of the mouth (a cleft palate), a large tongue (macroglossia),and a small lower jaw (micrognathia). Bones are affected by slight platyspondylisis and large, often defective epiphyses. Juvenile joint laxity is followed by early signs of arthrosis.The degree of hearing loss varies among affected individuals and may become more severe over time. Syndrome expressivity is variable.,Domain:Each subunit is composed of three triple-helical domains interspersed with non-collagenous domains. The globular domain at the N-terminus of type IX collagen molecules represents the NC4 domain which may participate in electrostatic interactions with polyanionic glycosaminoglycans in cartilage.,Function:Structural component of hyaline cartilage and vitreous of the eye.,PTM:Covalently linked to the telopeptides of type II collagen by lysine-derived cross links.,PTM:Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in someor all of the chains.,similarity:Belongs to the fibril-associated collagens with interrupted helices (FACIT) family.,similarity:Contains 1 TSP N-terminal (TSPN) domain.,subunit:Heterotrimer of an alpha 1(IX), an alpha 2(IX) and an alpha 3(IX) chain.
• Preparation and Storage: Store at -15 degree C to -25 degree C/1 year (Do not lower than -25 degree C)

IHC (Immunohiostchemistry)

(Immunohistochemical analysis of paraffin- embedded human tonsil. 1,Antibody was diluted at 1:200 (4 degree C overnight). 2, Tris-EDTA, pH9.0 was used for antigen retrieval. 3, Secondary antibody was diluted at 1:200(room temperature, 30min).)

WB (Western Blot)

(Western Blot analysis of HepG2 cells using COL9A1 Polyclonal Antibody.)

NCBI and Uniprot Product Information

• NCBI GI #: 73486666
• NCBI GeneID: 1297
• NCBI Accession #: NP_001842.3
• NCBI GenBank Nucleotide #: NP_001842.3
• UniProt Accession #: P20849
• Molecular Weight: 120kD (Observed)
• NCBI Official Full Name: collagen alpha-1(IX) chain isoform 1
• NCBI Official Synonym Full Names: collagen type IX alpha 1 chain
• NCBI Official Symbol: COL9A1
• NCBI Official Synonym Symbols: MED; EDM6; STL4; DJ149L1.1.2
• NCBI Protein Information: collagen alpha-1(IX) chain
• UniProt Protein Name: Collagen alpha-1(IX) chain
• UniProt Gene Name: COL9A1
• UniProt Entry Name: CO9A1_HUMAN