Rabbit CPLX2 Polyclonal Antibody | anti-CPLX2 antibody

CPLX2 Antibody (Center)

Cat. Num. AAA284066

• Gene Names: CPLX2; CPX2; Hfb1; 921-L; CPX-2
• Reactivity: Mouse (Predicted Reactivity: Bovine, Rat)
• Applications: ELISA, Western Blot
• Purity: This antibody is purified through a protein A column, followed by peptide affinity purification.
• Synonyms: CPLX2, Antibody; CPLX2 Antibody (Center); Complexin-2; Complexin II; CPX II; Synaphin-1; CPLX2; anti-CPLX2 antibody

• Host: Rabbit
• Reactivity: Mouse (Predicted Reactivity: Bovine, Rat)
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: This CPLX2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 51-83 amino acids from the Central region of human CPLX2.
• Purity/Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.
• Form/Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
• Sequence Length: 134

• Applicable Applications for anti-CPLX2 antibody: ELISA, WB (Western Blot)
• Function: Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Also involved in mast cell exocytosis (By similarity).
• Cellular Location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P84087}. Presynapse {ECO:0000250|UniProtKB:P84087}. Nucleus {ECO:0000250|UniProtKB:P84087} Perikaryon {ECO:0000250|UniProtKB:P84087}. Note=Translocated from the perikaryon to the presynaptic terminals during maturation of neuronal cells. In mast cells, cytosol and nucleus. Becomes enriched near plasma membrane following stimulation. {ECO:0000250|UniProtKB:P84087}
• Tissue Location: Nervous system. In hippocampus and cerebellum, expressed mainly by excitatory neurons. Down-regulated in brain cortex from patients suffering from Huntington disease, bipolar disorder or major depression. Down-regulated in cerebellum from patients with schizophrenia.
• Preparation and Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

WB (Western Blot)

(Western blot analysis of lysate from mouse brain tissue, using CPLX2 Antibody (Center). AAA284066 was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug.)

Related Product Information for anti-CPLX2 antibody

Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in synaptic vesicle exocytosis. Also involved in mast cell exocytosis (By similarity).

Product Categories/Family for anti-CPLX2 antibody

Crown Antibodies; Immunology; Signal Transduction

References

McMahon H.T.,et al.Cell 83:111-119(1995).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Raevskaya N.M.,et al.Gene 359:127-137(2005).
Harrison P.J.,et al.Lancet 352:1669-1673(1998).
Eastwood S.L.,et al.Brain Res. Bull. 55:569-578(2001).

NCBI and Uniprot Product Information

• NCBI GI #: 56550065
• NCBI GeneID: 10814
• NCBI Accession #: NP_001008221.1
• NCBI GenBank Nucleotide #: NM_001008220.1
• UniProt Accession #: Q6PUV4; O09056; Q13329; Q28184; Q52M15; Q64386; B2RAG2
• Molecular Weight: 15394
• NCBI Official Full Name: complexin-2
• NCBI Official Synonym Full Names: complexin 2
• NCBI Official Symbol: CPLX2
• NCBI Official Synonym Symbols: CPX2; Hfb1; 921-L; CPX-2
• NCBI Protein Information: complexin-2
• UniProt Protein Name: Complexin-2
• UniProt Gene Name: CPLX2
• UniProt Synonym Gene Names: CPX II
• UniProt Entry Name: CPLX2_HUMAN