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IHC (Immunohistochemistry)
(CTSS/Cathepsin S Antibody-Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE))
Rabbit anti-Mouse, Human CTSS/Cathepsin S Polyclonal Antibody | anti-CTSS antibody
CTSS/Cathepsin S Rabbit anti-Human Polyclonal Antibody
Reactivity
Mouse, Human
Applications
Western Blot, Immunohistochemistry
Purity
Immunoaffinity chromatography
Synonyms
CTSS/Cathepsin S, Antibody; CTSS/Cathepsin S Rabbit anti-Human Polyclonal Antibody; PathPlus CTSS/Cathepsin S Antibody; CTSS; Cathepsin S; Cat-s; CATS; anti-CTSS antibody
Host
Rabbit
Reactivity
Mouse, Human
Clonality
Polyclonal
Specificity
Recognizes endogenous levels of Cathepsin S protein.
Purity/Purification
Immunoaffinity chromatography
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH7.3, 30% glycerol, and 0.01% sodium azide.
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-CTSS antibody
WB (Western Blot), IHC (Immunohistochemistry)
Target
Human CTSS/Cathepsin S
Immunogen
Recombinant full length protein of human Cathepsin S
Conjugation
Unconjugated
Family
Protease
Subfamily
Cysteine C1
Preparation and Storage
Aliquot and store at -20 degree C for 1 year. Avoid freeze/thaw cycles.
IHC (Immunohistochemistry)
(CTSS/Cathepsin S Antibody-Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohistochemistry)
(CTSS/Cathepsin S Antibody-Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohistochemisry)
(CTSS/Cathepsin S Antibody-Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohistochemisry)
(CTSS/Cathepsin S Antibody-Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohiostchemistry)
(CTSS/Cathepsin S Antibody-Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohiostchemistry)
(CTSS/Cathepsin S Antibody-Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE))
WB (Western Blot)
(CTSS/Cathepsin S Antibody)
WB (Western Blot)
(CTSS/Cathepsin S Antibody)
Related Product Information for anti-CTSS antibody
Cathepsin S antibody is an unconjugated rabbit polyclonal antibody to Cathepsin S (CTSS) from human. It is reactive with human and mouse. Validated for IHC and WB.
CTSS (Cathepsin S) is a lysosomal cysteine protease of the papain family that functions as a potent elastase in alveolar macrophages and degrades proteins for antigen presentation to the MHC Class II complex. It is found in macrophages, B-lymphocytes, microglia, dendritic cells and populations of epithelial cells. Due to its ability to cleave a wide range of substrates and its role in blood vessel angiogenesis and permeability, it also promotes tumor growth. It is a prognostic marker for a number of cancers including type IV astrocytomas, where it is upregulated, and also a target of inhibition therapies. Suppression of cathpesin S has also been shown to be protective after brain injury. In immunohistochemistry of normal tissue, CTSS has cytoplasmic positivity throughout most of the body.
CTSS (Cathepsin S) is a lysosomal cysteine protease of the papain family that functions as a potent elastase in alveolar macrophages and degrades proteins for antigen presentation to the MHC Class II complex. It is found in macrophages, B-lymphocytes, microglia, dendritic cells and populations of epithelial cells. Due to its ability to cleave a wide range of substrates and its role in blood vessel angiogenesis and permeability, it also promotes tumor growth. It is a prognostic marker for a number of cancers including type IV astrocytomas, where it is upregulated, and also a target of inhibition therapies. Suppression of cathpesin S has also been shown to be protective after brain injury. In immunohistochemistry of normal tissue, CTSS has cytoplasmic positivity throughout most of the body.
References
Am J Pathol. 2003 Jul;163(1):175-82, PMID: 12819022; Mediators of Inflammation. 2013 (2013): 187873, PMID: 24282339; Mol Cancer. 2014 Mar 2;13:43, PMID: 24580730; Mol Cancer. 2016 Apr 21;15:29, PMID: 27097645; Neoplasma. 2015;62(1):16-26, PMID: 25563363; Cancer Genomics Proteomics. 2009 May-Jun;6(3):149-59, PMID: 19487544
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
31,626 Da
NCBI Official Full Name
cathepsin S isoform 1 preproprotein
NCBI Official Synonym Full Names
cathepsin S
NCBI Official Symbol
CTSS
NCBI Protein Information
cathepsin S
UniProt Protein Name
Cathepsin S
UniProt Gene Name
CTSS
UniProt Entry Name
CATS_HUMAN
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Product Notes
The CTSS ctss (Catalog #AAA163333) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CTSS/Cathepsin S Rabbit anti-Human Polyclonal Antibody reacts with Mouse, Human and may cross-react with other species as described in the data sheet. AAA Biotech's CTSS/Cathepsin S can be used in a range of immunoassay formats including, but not limited to, WB (Western Blot), IHC (Immunohistochemistry). Researchers should empirically determine the suitability of the CTSS ctss for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CTSS/Cathepsin S, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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