IHC (Immunohiostchemistry)
(CXCR5 Antibody Immunohistochemistry on an FFPE Lung Adenocarcinoma Tissue)
Rabbit anti-Human CXCR5/CD185 Polyclonal Antibody | anti-CXCR5/CD185 antibody
CXCR5/CD185 (Polyclonal)
Reactivity
Human
Synonyms
CXCR5/CD185, Antibody; CXCR5/CD185 (Polyclonal); cxcr5; anti-cxcr5; cd185; anti-cd185; g-protein coupled receptor;anti-g-protein; gpcr; anti-gpcr; anti-CXCR5/CD185 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Form/Format
Paraffin, Frozen
CXCR5 is a rabbit polyclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
CXCR5 is a rabbit polyclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
Immunogen
Recombinant human CXCR5 protein.
Control
Placenta, Brain, Lung, Transitional Cell Carcinoma, Testis, Ovarian Serous Carcinoma, Hepatocellular Carcinoma
Localization
Cytoplasmic, Membranous
Preparation and Storage
Store at 2-8 degree C (Control Slides: Store at 20-25 degree C)
IHC (Immunohiostchemistry)
(CXCR5 Antibody Immunohistochemistry on an FFPE Lung Adenocarcinoma Tissue)
IHC (Immunohiostchemistry)
(CXCR5 Antibody Immunohistochemistry on an FFPE Lung Adenocarcinoma Tissue)
Dilution Info
Dilution Info
Related Product Information for anti-CXCR5/CD185 antibody
The G-protein coupled receptor (GPCR) or C-X-C motif chemokine receptor 5, CXCR5, also known as or Burkitt lymphoma receptor 1 (BLR1), plays fundamental roles in inflammatory, infectious and immune responses. Current evidence also indicates that the CXCL13:CXCR5 axis orchestrates cell-cell interactions that regulate lymphocyte infiltration within the tumor microenvironment, thereby determining responsiveness to cytotoxic and immune-targeted therapies. CXCR5 is expressed in mature B-cells and Burkitt's lymphoma. This cytokine receptor binds to B-lymphocyte chemoattractant (BLC), and is involved in B-cell migration into B-cell follicles of spleen and Peyer patches.
CXCR5 antibody is highly expressed in primary and secondary follicles within gastric lymphomas. non-small cell lung cancer (NSCLC) tissues express CXCR5, which correlates with stage/grade of the disease. Higher CXCR5 expression and migration by NSCLC cells suggest a role in migration and metastasis of primary lung tumors in response to CXCL13. These findings indicate that differential expression patterns of CXCR5 and CXCL13 in two subtypes (squamous cell carcinoma and adenocarcinoma) of NSCLC are associated with differences in their prognosis and survival. It has been proposed that CXCR5/CXCL13, either alone or in combination, could be used as a prognostic biomarker for lung cancer. Other studies have shown that CXCR5 overexpression in breast cancer patients highly correlates with lymph node metastases, and elevated CXCR5 antibody expression may contribute to abnormal cell survival and migration in breast tumors that lack functional p53 protein. Another study has indicated that prostate cancer tissue as well as cell lines express higher non-basal levels of CXCR5 and found a correlation between the level of CXCR5 and Gleason score. CXCR5 location was additionally considered and higher Gleason scores correlated with nuclear CXCR5 while cytoplasmic and membrane CXCR5 correlated with benign and early prostate cancers.
CXCR5 antibody is highly expressed in primary and secondary follicles within gastric lymphomas. non-small cell lung cancer (NSCLC) tissues express CXCR5, which correlates with stage/grade of the disease. Higher CXCR5 expression and migration by NSCLC cells suggest a role in migration and metastasis of primary lung tumors in response to CXCL13. These findings indicate that differential expression patterns of CXCR5 and CXCL13 in two subtypes (squamous cell carcinoma and adenocarcinoma) of NSCLC are associated with differences in their prognosis and survival. It has been proposed that CXCR5/CXCL13, either alone or in combination, could be used as a prognostic biomarker for lung cancer. Other studies have shown that CXCR5 overexpression in breast cancer patients highly correlates with lymph node metastases, and elevated CXCR5 antibody expression may contribute to abnormal cell survival and migration in breast tumors that lack functional p53 protein. Another study has indicated that prostate cancer tissue as well as cell lines express higher non-basal levels of CXCR5 and found a correlation between the level of CXCR5 and Gleason score. CXCR5 location was additionally considered and higher Gleason scores correlated with nuclear CXCR5 while cytoplasmic and membrane CXCR5 correlated with benign and early prostate cancers.
Similar Products
Product Notes
The CXCR5/CD185 (Catalog #AAA59365) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CXCR5/CD185 (Polyclonal) reacts with Human and may cross-react with other species as described in the data sheet. It is sometimes possible for the material contained within the vial of "CXCR5/CD185, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.