Rabbit CXXC4 Polyclonal Antibody | anti-CXXC4 antibody

CXXC4 Antibody

Cat. Num. AAA39990

• Gene Names: CXXC4; IDAX
• Reactivity: Human, Mouse, Rat
• Applications: Immunofluorescence, Immunohistochemistry, Western Blot, ELISA
• Purity: CXXC4 Antibody is affinity chromatography purified via peptide column.
• Synonyms: CXXC4, Antibody; CXXC4 Antibody; CXXC4; IDAX; CXXC-type zinc finger protein 4; Inhibition of the Dvl and axin complex protein; CXXC finger protein 4; anti-CXXC4 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: CXXC4 Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 198

• Applicable Applications for anti-CXXC4 antibody: IF (Immunofluorescence), IHC (Immunohistochemistry), WB (Western Blot), ELISA
• Conjugate: Unconjugated
• Immunogen: CXXC4 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human CXXC4.
• Buffer: CXXC4 Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: CXXC4 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IF (Immunofluorescence)

(Immunofluorescence of CXXC4 in human brain tissue with CXXC4 antibody at 20 μg/mL.)

IHC (Immunohiostchemistry)

(Immunohistochemistry of CXXC4 in human brain tissue with CXXC4 antibody at 10 μg/mL.)

WB (Western Blot)

(Western blot analysis of CXXC4 in human brain tissue lysate with CXXC4 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.)

Related Product Information for anti-CXXC4 antibody

CXXC4 Antibody: CXXC4 is zinc finger protein that binds directly to the PDZ domain of DVL1, a protein involved in the Wnt signaling pathway, through its C-terminal region. CXXC4's interaction with DVL1 competes with DVL1-AXIN binding, although the affinity of DVL1 for CXXC4 is lower than that for AXIN. In mouse fibroblasts, CXXC4 suppressed Wnt3a induction of beta-catenin and inhibited Wnt3a-dependent TCF4 activation, suggesting that CXXC4 acts as a negative regulator of the Wnt signaling pathway and functions between DVL and beta-catenin. Recent reports suggest that decreased CXXC4 expression is associated with kidney cancer metastasis, cell proliferation, reduced apoptosis in response to cancer drugs, and upregulation of genes involved with proliferation, invasion and cell survival, suggesting that CXXC4 plays a critical role in tumor progression in kidney cancer.

NCBI and Uniprot Product Information

• NCBI GI #: 13376816
• NCBI GeneID: 80319
• NCBI Accession #: NP_079488
• NCBI GenBank Nucleotide #: NM_025212.1
• UniProt Accession #: Q9H2H0
• Molecular Weight: 20,978 Da
• NCBI Official Full Name: CXXC-type zinc finger protein 4
• NCBI Official Synonym Full Names: CXXC finger protein 4
• NCBI Official Symbol: CXXC4
• NCBI Official Synonym Symbols: IDAX
• NCBI Protein Information: CXXC-type zinc finger protein 4; CXXC finger 4; inhibition of the Dvl and axin complex protein; Dvl-binding protein IDAX (inhibition of the Dvl and Axin complex)
• UniProt Protein Name: CXXC-type zinc finger protein 4
• UniProt Gene Name: CXXC4
• UniProt Synonym Gene Names: IDAX
• UniProt Entry Name: CXXC4_HUMAN