IHC (Immunohiostchemistry)
(Immunohistochemistry of CXXC4 in human brain tissue with CXXC4 antibody at 10 ug/mL.)
Rabbit CXXC4 Polyclonal Antibody | anti-CXXC4 antibody
CXXC4 Antibody
Gene Names
CXXC4; IDAX
Reactivity
Human, Mouse, Rat
Applications
Immunohistochemistry, Western Blot, ELISA
Purity
Affinity chromatography purified via peptide column
Synonyms
CXXC4, Antibody; CXXC4 Antibody; CXXC-type zinc finger protein 4, IDAX; anti-CXXC4 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Purity/Purification
Affinity chromatography purified via peptide column
Form/Format
Supplied in PBS containing 0.02% sodium azide.
Concentration
1 mg/ml (varies by lot)
Sequence Length
367
Applicable Applications for anti-CXXC4 antibody
IHC (Immunohistochemistry), WB (Western Blot), ELISA
Immunogen Type
Peptide
Immunogen Description
Raised against an 18 amino acid peptide near the amino terminus of human CXXC4.
Target Name
CXXC4
Preparation and Storage
Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
IHC (Immunohiostchemistry)
(Immunohistochemistry of CXXC4 in human brain tissue with CXXC4 antibody at 10 ug/mL.)
IHC (Immunohiostchemistry)
(Immunohistochemistry of CXXC4 in human brain tissue with CXXC4 antibody at 10 ug/mL.)
WB (Western Blot)
(Western blot analysis of CXXC4 in human brain tissue lysate with CXXC4 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.)
WB (Western Blot)
(Western blot analysis of CXXC4 in human brain tissue lysate with CXXC4 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.)
Related Product Information for anti-CXXC4 antibody
CXXC4 is zinc finger protein that binds directly to the PDZ domain of DVL1, a protein involved in the Wnt signaling pathway, through its C-terminal region. CXXC4's interaction with DVL1 competes with DVL1-AXIN binding, although the affinity of DVL1 for CXXC4 is lower than that for AXIN. In mouse fibroblasts, CXXC4 suppressed Wnt3a induction of beta-catenin and inhibited Wnt3a-dependent TCF4 activation, suggesting that CXXC4 acts as a negative regulator of the Wnt signaling pathway and functions between DVL and beta-catenin. Recent reports suggest that decreased CXXC4 expression is associated with kidney cancer metastasis, cell proliferation, reduced apoptosis in response to cancer drugs, and upregulation of genes involved with proliferation, invasion and cell survival, suggesting that CXXC4 plays a critical role in tumor progression in kidney cancer.
Product Categories/Family for anti-CXXC4 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
NCBI Official Full Name
CXXC-type zinc finger protein 4
NCBI Official Synonym Full Names
CXXC finger protein 4
NCBI Official Symbol
CXXC4
NCBI Official Synonym Symbols
IDAX
NCBI Protein Information
CXXC-type zinc finger protein 4
UniProt Protein Name
CXXC-type zinc finger protein 4
UniProt Gene Name
CXXC4
UniProt Synonym Gene Names
IDAX
UniProt Entry Name
CXXC4_HUMAN
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Product Notes
The CXXC4 cxxc4 (Catalog #AAA303787) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CXXC4 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's CXXC4 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), WB (Western Blot), ELISA. Researchers should empirically determine the suitability of the CXXC4 cxxc4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CXXC4, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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