CYP1B1 Polyclonal Antibody | anti-CYP1B1 antibody

Anti-CYP1B1 Antibody

Cat. Num. AAA46484

• Gene Names: CYP1B1; CP1B; GLC3A; CYPIB1; P4501B1
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry, Western Blot
• Purity: Immunogen Affinity Purified
• Synonyms: CYP1B1, Antibody; Anti-CYP1B1 Antibody; Cytochrome P450 1B1; Aryl hydrocarbon hydroxylase; CP1B; CP1B1_HUMAN; Cyp1b1; CYPIB1; Cytochrome P450 family 1 subfamily B polypeptide 1; Cytochrome P450 subfamily I (dioxin inducible) polypeptide 1 (glaucoma 3 primary infantile); Flavoprotein linked monooxygenase; GLC3A; Microsomal monooxygenase; P4501B1; Xenobiotic monooxygenase; cytochrome P450, family 1, subfamily B, polypeptide 1; anti-CYP1B1 antibody

• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: No cross-reactivity with other proteins.
• Purity/Purification: Immunogen Affinity Purified
• Form/Format: Lyophilized. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na₂HPO₄, 0.05mg NaN₃.
• Sequence Length: 543

• Applicable Applications for anti-CYP1B1 antibody: IHC (Immunohistochemistry), WB (Western Blot)
• Immunogen: E Coli-derived human CYP1B1 recombinant protein (Position: R255-L480). Human CYP1B1 shares 85.4% and 84.5% amino acid (aa) sequence identity with mouse and rat CYP1B1, respectively.
• Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
• Preparation and Storage: Store at -20°C. After reconstitution, store at 4°C. It can also be aliquoted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.

IHC (Immunohistochemistry)

(Anti- CYP1B1 Picoband antibody, AAA46484,IHC(P)IHC(P): Human Liver Cancer Tissue)

IHC (Immunohistochemisry)

(Anti- CYP1B1 Picoband antibody, AAA46484,IHC(P)IHC(P): Rat Kidney Tissue)

IHC (Immunohiostchemistry)

(Anti- CYP1B1 Picoband antibody, AAA46484,IHC(P)IHC(P): Mouse Kidney Tissue)

WB (Western Blot)

(Anti- CYP1B1 Picoband antibody, AAA46484, Western blottingAll lanes: Anti CYP1B1 (AAA46484) at 0.5ug/mlLane 1: Rat Kidney Tissue Lysate at 50ugLane 2: MCF-7 Whole Cell Lysate at 40ugPredicted bind size: 61KDObserved bind size: 61KD)

Related Product Information for anti-CYP1B1 antibody

Cytochrome P450 1B1 is an enzyme that in humans is encoded by the CYP1B1 gene. CYP1B1 belongs to the the cytochrome P450 superfamilyof enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis ofcholesterol, steroids and other lipids. The enzyme encoded by this gene localizes to the endoplasmic reticulum and metabolizes procarcinogenssuch as polycyclic aromatic hydrocarbons and 17beta-estradiol. Mutations in this gene have been associated with primary congenital glaucoma;therefore it is thought that the enzyme also metabolizes a signaling molecule involved in eye development, possibly a steroid.

References

1. "Entrez Gene: cytochrome P450". 2. Bailey LR, Roodi N, Dupont WD, Parl FF (1998). "Association of cytochrome P450 1B1 (CYP1B1) polymorphism with steroid receptor status in breast cancer.". Cancer Res. 58 (22): 5038-41. 3. Michels-Rautenstrauss KG, Mardin CY, Zenker M et al. (2002). "Primary congenital glaucoma: three case reports on novel mutations and combinations of mutations in the GLC3A (CYP1B1) gene.". J. Glaucoma 10 (4): 354-7.

NCBI and Uniprot Product Information

• NCBI GI #: 189491763
• NCBI GeneID: 1545
• NCBI Accession #: NP_000095.2
• NCBI GenBank Nucleotide #: NM_000104.3
• UniProt Accession #: Q16678; Q5TZW8; Q93089; Q9H316
• NCBI Official Full Name: cytochrome P450 1B1
• NCBI Official Synonym Full Names: cytochrome P450 family 1 subfamily B member 1
• NCBI Official Symbol: CYP1B1
• NCBI Official Synonym Symbols: CP1B; GLC3A; CYPIB1; P4501B1
• NCBI Protein Information: cytochrome P450 1B1
• UniProt Protein Name: Cytochrome P450 1B1
• UniProt Gene Name: CYP1B1
• UniProt Entry Name: CP1B1_HUMAN