IF (Immunofluorescence)
(Confocal immunofluorescent analysis of CYP2B6 Antibody (Center) with 293 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).)
Rabbit anti-Human CYP2B6 Polyclonal Antibody | anti-CYP2B6 antibody
CYP2B6 Antibody (Center)
Gene Names
CYP2B6; CPB6; EFVM; IIB1; P450; CYP2B; CYP2B7; CYP2B7P; CYPIIB6
Reactivity
Human
Applications
Immunohistochemistry, Western Blot, ELISA, Immunofluorescence
Purity
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
CYP2B6, Antibody; CYP2B6 Antibody (Center); Cytochrome P450 2B6; 11413-,4-cineole 2-exo-monooxygenase; CYPIIB6; Cytochrome P450 IIB1; CYP2B6; anti-CYP2B6 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This CYP2B6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 235-263 amino acids from the Central region of human CYP2B6.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.36 (varies by lot)
Sequence Positions
235-263
Sequence Length
491
Applicable Applications for anti-CYP2B6 antibody
IHC (Immunohistochemistry), WB (Western Blot), ELISA, IF (Immunofluorescence)
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
IF (Immunofluorescence)
(Confocal immunofluorescent analysis of CYP2B6 Antibody (Center) with 293 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).)
IF (Immunofluorescence)
(Confocal immunofluorescent analysis of CYP2B6 Antibody (Center) with 293 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).)
IHC (Immunohiostchemistry)
(CYP2B6 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human hepatocarcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of CYP2B6 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
IHC (Immunohiostchemistry)
(CYP2B6 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human hepatocarcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of CYP2B6 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
WB (Western Blot)
(CYP2B6 Antibody (Center) western blot analysis in 293(lane 1) and K562(lane 2) cell line lysates (35ug/lane).This demonstrates the CYP2B6 antibody detected the CYP2B6 protein (arrow).)
WB (Western Blot)
(CYP2B6 Antibody (Center) western blot analysis in 293(lane 1) and K562(lane 2) cell line lysates (35ug/lane).This demonstrates the CYP2B6 antibody detected the CYP2B6 protein (arrow).)
Related Product Information for anti-CYP2B6 antibody
This gene, CYP2B6, encodes a member of the cytochrome P450
superfamily of enzymes. The cytochrome P450 proteins are
monooxygenases which catalyze many reactions involved in drug
metabolism and synthesis of cholesterol, steroids and other lipids.
This protein localizes to the endoplasmic reticulum and its
expression is induced by phenobarbital. The enzyme is known to
metabolize some xenobiotics, such as the anti-cancer drugs
cyclophosphamide and ifosphamide. Transcript variants for this gene
have been described; however, it has not been resolved whether
these transcripts are in fact produced by this gene or by a closely
related pseudogene, CYP2B7. Both the gene and the pseudogene are
located in the middle of a CYP2A pseudogene found in a large
cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F
subfamilies on chromosome 19q.
superfamily of enzymes. The cytochrome P450 proteins are
monooxygenases which catalyze many reactions involved in drug
metabolism and synthesis of cholesterol, steroids and other lipids.
This protein localizes to the endoplasmic reticulum and its
expression is induced by phenobarbital. The enzyme is known to
metabolize some xenobiotics, such as the anti-cancer drugs
cyclophosphamide and ifosphamide. Transcript variants for this gene
have been described; however, it has not been resolved whether
these transcripts are in fact produced by this gene or by a closely
related pseudogene, CYP2B7. Both the gene and the pseudogene are
located in the middle of a CYP2A pseudogene found in a large
cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F
subfamilies on chromosome 19q.
Product Categories/Family for anti-CYP2B6 antibody
References
Figueroa, S.C., et al. Ther Drug Monit 32(5):579-585(2010)
Chou, M., et al. Antimicrob. Agents Chemother. 54(10):4432-4439(2010)
Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)
Bunten, H., et al. Clin. Pharmacol. Ther. 88(3):383-389(2010)
Gounden, V., et al. AIDS Res Ther 7, 32 (2010) :
Chou, M., et al. Antimicrob. Agents Chemother. 54(10):4432-4439(2010)
Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)
Bunten, H., et al. Clin. Pharmacol. Ther. 88(3):383-389(2010)
Gounden, V., et al. AIDS Res Ther 7, 32 (2010) :
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
56278
NCBI Official Full Name
cytochrome P450 2B6
NCBI Official Synonym Full Names
cytochrome P450, family 2, subfamily B, polypeptide 6
NCBI Official Symbol
CYP2B6
NCBI Official Synonym Symbols
CPB6; EFVM; IIB1; P450; CYP2B; CYP2B7; CYP2B7P; CYPIIB6
NCBI Protein Information
cytochrome P450 2B6
UniProt Protein Name
Cytochrome P450 2B6
UniProt Gene Name
CYP2B6
UniProt Entry Name
CP2B6_HUMAN
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Product Notes
The CYP2B6 cyp2b6 (Catalog #AAA288318) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 235-263. The CYP2B6 Antibody (Center) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CYP2B6 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), WB (Western Blot), ELISA, IF (Immunofluorescence). Researchers should empirically determine the suitability of the CYP2B6 cyp2b6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CYP2B6, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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