IHC (Immunohiostchemistry)
(CYSLTR1 Antibody (Center) (AAA286882)immunohistochemistry analysis in formalin fixed and paraffin embedded human lung tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of CYSLTR1 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
Rabbit anti-Human CYSLTR1 Polyclonal Antibody | anti-CYSLTR1 antibody
CYSLTR1 Antibody (Center)
Gene Names
CYSLTR1; CYSLT1; CYSLTR; CYSLT1R; HMTMF81
Reactivity
Human
Applications
ELISA, Immunohistochemistry, Western Blot
Purity
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
CYSLTR1, Antibody; CYSLTR1 Antibody (Center); Cysteinyl leukotriene receptor 1; CysLTR1; Cysteinyl leukotriene D4 receptor; LTD4 receptor; G-protein coupled receptor HG55; HMTMF81; CYSLTR1; CYSLT1; anti-CYSLTR1 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This CYSLTR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 144-172 amino acids from the Central region of human CYSLTR1.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Sequence Positions
144-172
Sequence Length
337
Applicable Applications for anti-CYSLTR1 antibody
ELISA, IHC (Immunohistochemistry), WB (Western Blot)
Calculated MW
38541
Function
Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of
affinities for the leukotrienes is LTD4 >>LTE4 = LTC4 >> LTB4.
Cellular Location
Cell membrane; Multi-pass membrane protein
Tissue Location
Widely expressed, with highest levels in spleen and peripheral blood leukocytes. Lower expression in several tissues, such as lung (mostly in smooth muscle bundles and alveolar macrophages), placenta, small intestine, pancreas, colon and heart.
Preparation and Storage
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
IHC (Immunohiostchemistry)
(CYSLTR1 Antibody (Center) (AAA286882)immunohistochemistry analysis in formalin fixed and paraffin embedded human lung tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of CYSLTR1 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
IHC (Immunohiostchemistry)
(CYSLTR1 Antibody (Center) (AAA286882)immunohistochemistry analysis in formalin fixed and paraffin embedded human lung tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of CYSLTR1 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
WB (Western Blot)
(CYSLTR1 Antibody (Center) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the CYSLTR1 antibody detected the CYSLTR1 protein (arrow).)
WB (Western Blot)
(CYSLTR1 Antibody (Center) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the CYSLTR1 antibody detected the CYSLTR1 protein (arrow).)
Related Product Information for anti-CYSLTR1 antibody
The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are
important mediators of human bronchial asthma. Pharmacologic
studies have determined that cysteinyl leukotrienes activate at
least 2 receptors, the protein encoded by this gene and CYSLTR2.
This encoded receptor is a member of the superfamily of G
protein-coupled receptors. Activation of this receptor by LTD4
results in contraction and proliferation of smooth muscle, oedema,
eosinophil migration and damage to the mucus layer in the lung.
important mediators of human bronchial asthma. Pharmacologic
studies have determined that cysteinyl leukotrienes activate at
least 2 receptors, the protein encoded by this gene and CYSLTR2.
This encoded receptor is a member of the superfamily of G
protein-coupled receptors. Activation of this receptor by LTD4
results in contraction and proliferation of smooth muscle, oedema,
eosinophil migration and damage to the mucus layer in the lung.
Product Categories/Family for anti-CYSLTR1 antibody
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Boulay, M.E., et al. Prostaglandins Leukot. Essent. Fatty Acids 83(1):15-22(2010)
Schuurhof, A., et al. Pediatr. Pulmonol. 45(6):608-613(2010)
Hasegawa, S., et al. Platelets 21(4):253-259(2010)
Sokolowska, M., et al. BMC Immunol. 10, 63 (2009) :
Boulay, M.E., et al. Prostaglandins Leukot. Essent. Fatty Acids 83(1):15-22(2010)
Schuurhof, A., et al. Pediatr. Pulmonol. 45(6):608-613(2010)
Hasegawa, S., et al. Platelets 21(4):253-259(2010)
Sokolowska, M., et al. BMC Immunol. 10, 63 (2009) :
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
NCBI Official Full Name
cysteinyl leukotriene receptor 1
NCBI Official Synonym Full Names
cysteinyl leukotriene receptor 1
NCBI Official Symbol
CYSLTR1
NCBI Official Synonym Symbols
CYSLT1; CYSLTR; CYSLT1R; HMTMF81
NCBI Protein Information
cysteinyl leukotriene receptor 1
UniProt Protein Name
Cysteinyl leukotriene receptor 1
UniProt Gene Name
CYSLTR1
UniProt Synonym Gene Names
CYSLT1; CysLTR1; LTD4 receptor
UniProt Entry Name
CLTR1_HUMAN
Similar Products
Product Notes
The CYSLTR1 cysltr1 (Catalog #AAA286882) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 144-172. The CYSLTR1 Antibody (Center) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CYSLTR1 can be used in a range of immunoassay formats including, but not limited to, ELISA, IHC (Immunohistochemistry), WB (Western Blot). Researchers should empirically determine the suitability of the CYSLTR1 cysltr1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CYSLTR1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.