Rabbit anti-Human Cytoplasmic tyrosine-protein kinase BMX Polyclonal Antibody | anti-BMX antibody

Rabbit anti-human Cytoplasmic tyrosine-protein kinase BMX polyclonal Antibody(BMX)

Cat. Num. AAA119692

• Gene Names: BMX; ETK; PSCTK2; PSCTK3
• Reactivity: Human
• Applications: Immunohistochemistry, ELISA
• Purity: Antigen Affinity Purified
• Synonyms: Cytoplasmic tyrosine-protein kinase BMX, Antibody; Rabbit anti-human Cytoplasmic tyrosine-protein kinase BMX polyclonal Antibody(BMX); Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38), BMX; anti-BMX antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen Affinity Purified
• Form/Format: Liquid; PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Sequence Length: 675

• Applicable Applications for anti-BMX antibody: IHC (Immunohistochemistry), ELISA
• Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Conjugate: Non-conjugated
• Immunogen: Recombinant human Cytoplasmic tyrosine-protein kinase BMX protein (65-280aa)
• Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-8874 / sc-8873 / sc-20711
• Conjugate: Non-conjugated
• Species: Homo sapiens (Human)
• Research Area: Signal Transduction
• Target Names: BMX
• Preparation and Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

IHC (Immunohiostchemistry)

(Immunohistochemistry of paraffin-embedded human placenta tissue using AAA119692 at dilution 1:100)

IHC (Immunohistochemistry)

(Immunohistochemistry of paraffin-embedded human colon using AAA119692 at dilution 1:100)

Related Product Information for anti-BMX antibody

Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Plays also a role in programming adaptive cytoprotection against extracellular stress in different cell systems, salivary epithelial cells, brain endothelial cells, and dermal fibroblasts. May be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1. May also play a role in the growth and differentiation of hematopoietic cells; as well as in signal transduction in endocardial and arterial endothelial cells.

NCBI and Uniprot Product Information

• NCBI GI #: 4502435
• NCBI GeneID: 660
• NCBI Accession #: NP_001712.1
• NCBI GenBank Nucleotide #: NM_001721.6
• UniProt Accession #: P51813; O60564; Q12871; A6NIH9
• NCBI Official Full Name: cytoplasmic tyrosine-protein kinase BMX
• NCBI Official Synonym Full Names: BMX non-receptor tyrosine kinase
• NCBI Official Symbol: BMX
• NCBI Official Synonym Symbols: ETK; PSCTK2; PSCTK3
• NCBI Protein Information: cytoplasmic tyrosine-protein kinase BMX
• UniProt Protein Name: Cytoplasmic tyrosine-protein kinase BMX
• UniProt Gene Name: BMX
• UniProt Synonym Gene Names: ETK
• UniProt Entry Name: BMX_HUMAN