Rabbit DDB2 Polyclonal Antibody | anti-DDB2 antibody

DDB2 Antibody

Cat. Num. AAA303299

• Gene Names: DDB2; DDBB; UV-DDB2
• Reactivity: Human, Mouse, Rat
• Applications: Immunofluorescence, Immunohistochemistry, Western Blot
• Purity: Antibodies were purified by affinity purification using immunogen.
• Synonyms: DDB2, Antibody; DDB2 Antibody; DDBB; FLJ34321; UV-DDB2; anti-DDB2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous level of total DDB2 protein.
• Purity/Purification: Antibodies were purified by affinity purification using immunogen.
• Form/Format: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1.0 mg/ml (varies by lot)
• Sequence Length: 427

• Applicable Applications for anti-DDB2 antibody: IF (Immunofluorescence), IHC (Immunohistochemistry), WB (Western Blot)
• Immunogen Type: Recombinant Protein
• Immunogen Description: Recombinant protein of human DDB2.
• Target Name: DDB2
• Preparation and Storage: Store at -20 degree C

IF (Immunofluorescence)

(Immunofluorescence analysis of MCF7 cell using DDB2 antibody. Blue: DAPI for nuclear staining.)

IHC (Immunohistochemistry)

(Immunohistochemical analysis of paraffin-embedded human kidney cancer using DDB2 antibody at dilution of 1:200 (400x lens).)

IHC (Immunohistochemisry)

(Immunohistochemical analysis of paraffin-embedded human kidney cancer using DDB2 antibody at dilution of 1:200 (200x lens).)

IHC (Immunohiostchemistry)

(Immunohistochemical analysis of paraffin-embedded human kidney using DDB2 antibody at dilution of 1:200 (200x lens).)

WB (Western Blot)

(Western blot analysis of extracts of MCF-7 cell line, using DDB2 antibody.)

Related Product Information for anti-DDB2 antibody

Damaged DNA-Binding Protein (DDB) consists of a 127 kDa subunit (DDB-1) and a 48 kDa subunit (DDB-2) that contribute to the formation of the UV-damaged DNA-binding protein complex (UV-DDB) (1-3). In conjunction with CUL4A and ROC-1, the UV-DDB complex forms an E3 ubiquitin ligase that recognizes a broad spectrum of DNA lesions such as cyclobutane pyrimidine dimers, 6-4 photoproducts, apurinic sites and short mismatches. The complex polyubiquitinates components of the nucleotide excision repair pathway (4-6). Loss of DDB activity has been identified in a subset of xeroderma pigmentosum complementation group E (XP-E) patients and has been linked to the deficient repair of cyclobutane pyrimidine dimers in cells derived from these patients (7-10).

Product Categories/Family for anti-DDB2 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 4557515
• NCBI GeneID: 1643
• NCBI Accession #: NP_000098.1
• NCBI GenBank Nucleotide #: NM_000107.2
• UniProt Accession #: Q92466; Q76E54; Q76E55; Q76E56; Q76E57; B2R875
• Molecular Weight: 26,758 Da
• NCBI Official Full Name: DNA damage-binding protein 2
• NCBI Official Synonym Full Names: damage-specific DNA binding protein 2, 48kDa
• NCBI Official Symbol: DDB2
• NCBI Official Synonym Symbols: DDBB; UV-DDB2
• NCBI Protein Information: DNA damage-binding protein 2
• UniProt Protein Name: DNA damage-binding protein 2
• UniProt Gene Name: DDB2
• UniProt Synonym Gene Names: DDBb; UV-DDB 2
• UniProt Entry Name: DDB2_HUMAN