IHC (Immunohiostchemistry)
(DEGS2 antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the DEGS2 antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Rabbit DEGS2 Polyclonal Antibody | anti-DEGS2 antibody
DEGS2 Antibody (C-term)
Gene Names
DEGS2; DES2; FADS8; C14orf66
Reactivity
Human (Predicted Reactivity: Bovine, Mouse)
Applications
ELISA, Immunohistochemistry, Western Blot
Purity
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
DEGS2, Antibody; DEGS2 Antibody (C-term); Sphingolipid delta(4)-desaturase/C4-hydroxylase DES2; 1---; 114--; Degenerative spermatocyte homolog 2; DEGS2 HGNC:20113); C14orf66; anti-DEGS2 antibody
Host
Rabbit
Reactivity
Human (Predicted Reactivity: Bovine, Mouse)
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This DEGS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 261-290 amino acids from the C-terminal region of human DEGS2.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Sequence Positions
261-290
Applicable Applications for anti-DEGS2 antibody
ELISA, IHC (Immunohistochemistry), WB (Western Blot)
Function
Bifunctional enzyme which acts as both a sphingolipid delta(4)-desaturase and a sphingolipid C4-monooxygenase.
Cellular Location
Endoplasmic reticulum membrane{ECO:0000250|UniProtKB:Q8R2F2};Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8R2F2}
Tissue Location
Highly expressed in skin, intestine and kidney.
Preparation and Storage
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
IHC (Immunohiostchemistry)
(DEGS2 antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the DEGS2 antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
IHC (Immunohiostchemistry)
(DEGS2 antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the DEGS2 antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
WB (Western Blot)
(DEGS2 Antibody (C-term) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the DEGS2 antibody detected the DEGS2 protein (arrow).)
WB (Western Blot)
(DEGS2 Antibody (C-term) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the DEGS2 antibody detected the DEGS2 protein (arrow).)
Related Product Information for anti-DEGS2 antibody
DEGS2 encodes a bifunctional enzyme that is involved in the biosynthesis of phytosphingolipids in human skin and in >other phytosphingolipid-containing tissues. This enzyme can act as a sphingolipid delta(4)-desaturase, and also as a sphingolipid C4-hydroxylase.
References
Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)
Oh, J.H., et al. Mamm. Genome 16(12):942-954(2005)
Mizutani, Y., et al. FEBS Lett. 563 (1-3), 93-97 (2004) :
Oh, J.H., et al. Mamm. Genome 16(12):942-954(2005)
Mizutani, Y., et al. FEBS Lett. 563 (1-3), 93-97 (2004) :
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
37197
NCBI Official Full Name
sphingolipid delta(4)-desaturase/C4-hydroxylase DES2
NCBI Official Synonym Full Names
delta(4)-desaturase, sphingolipid 2
NCBI Official Symbol
DEGS2
NCBI Official Synonym Symbols
DES2; FADS8; C14orf66
NCBI Protein Information
sphingolipid delta(4)-desaturase/C4-hydroxylase DES2
UniProt Protein Name
Sphingolipid delta(4)-desaturase/C4-hydroxylase DES2
UniProt Gene Name
DEGS2
UniProt Entry Name
DEGS2_HUMAN
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Product Notes
The DEGS2 degs2 (Catalog #AAA289726) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 261-290. The DEGS2 Antibody (C-term) reacts with Human (Predicted Reactivity: Bovine, Mouse) and may cross-react with other species as described in the data sheet. AAA Biotech's DEGS2 can be used in a range of immunoassay formats including, but not limited to, ELISA, IHC (Immunohistochemistry), WB (Western Blot). Researchers should empirically determine the suitability of the DEGS2 degs2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "DEGS2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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