Rabbit DLAT Polyclonal Antibody | anti-DLAT antibody

DLAT antibody

Cat. Num. AAA303083

• Gene Names: DLAT; DLTA; PDCE2; PDC-E2
• Reactivity: Human, Mouse, Rat
• Applications: Immunofluorescence, Western Blot
• Purity: Antibodies were purified by affinity purification using immunogen.
• Synonyms: DLAT, Antibody; DLAT antibody; DLTA; PDCE2; PDC-E2; anti-DLAT antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous level of total DLAT antibody.
• Purity/Purification: Antibodies were purified by affinity purification using immunogen.
• Form/Format: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1.0 mg/ml (varies by lot)

• Applicable Applications for anti-DLAT antibody: IF (Immunofluorescence), WB (Western Blot)
• Immunogen Type: Recombinant Protein
• Immunogen Description: Recombinant protein of human DLAT.
• Target Name: DLAT
• Preparation and Storage: Store at -20°C

IF (Immunofluorescence)

(Immunofluorescence analysis of HeLa cell using DLAT antibody. Blue: DAPI for nuclear staining.)

WB (Western Blot)

(Western blot analysis of extracts of various cell lines, using DLAT at 1:1000 dilution.)

Related Product Information for anti-DLAT antibody

This gene encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC enventually leads to cirrhosis and liver failure. Mutations in this gene are also a cause of pyruvate dehydrogenase E2 deficiency which causes primary lactic acidosis in infancy and early childhood.

Product Categories/Family for anti-DLAT antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 31711992
• NCBI GeneID: 1737
• NCBI Accession #: NP_001922.2
• NCBI GenBank Nucleotide #: NM_001931.4
• UniProt Accession #: P10515; Q16783; Q53EP3
• Molecular Weight: SDS-PAGE: 68kd
• NCBI Official Full Name: dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
• NCBI Official Synonym Full Names: dihydrolipoamide S-acetyltransferase
• NCBI Official Symbol: DLAT
• NCBI Official Synonym Symbols: DLTA; PDCE2; PDC-E2
• NCBI Protein Information: dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
• UniProt Protein Name: Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
• UniProt Gene Name: DLAT
• UniProt Synonym Gene Names: DLTA; PBC; PDC-E2; PDCE2
• UniProt Entry Name: ODP2_HUMAN