IHC (Immunohiostchemistry)
(Immunohistochemistry of paraffin-embedded human heart tissue AAA230203 at dilution 1:100)
Rabbit anti-Human DNA2 Polyclonal Antibody | anti-DNA2 antibody
DNA2 Antibody
Gene Names
DNA2; DNA2L; hDNA2
Reactivity
Human
Applications
Immunohistochemistry, ELISA
Purity
>95%,Protein G purified
Synonyms
DNA2, Antibody; DNA2 Antibody; DNA replication ATP-dependent helicase/nuclease DNA2; hDNA2; DNA replication ATP-dependent helicase-like homolog; DNA2; DNA2L; KIAA0083; anti-DNA2 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
>95%,Protein G purified
Form/Format
Liquid
Sequence Length
1060
Applicable Applications for anti-DNA2 antibody
IHC (Immunohistochemistry), ELISA
Immunogen
Recombinant human DNA replication ATP-dependent helicase/nuclease DNA2 protein
Conjugation
Non-conjugated
Storage Buffer
Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-138770 / sc-138771 / sc-138772
Preparation and Storage
Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
IHC (Immunohiostchemistry)
(Immunohistochemistry of paraffin-embedded human heart tissue AAA230203 at dilution 1:100)
IHC (Immunohiostchemistry)
(Immunohistochemistry of paraffin-embedded human heart tissue AAA230203 at dilution 1:100)
IHC (Immunohistochemistry)
(Immunohistochemistry of paraffin-embedded human kidney tissue AAA230203 at dilution 1:100)
IHC (Immunohistochemistry)
(Immunohistochemistry of paraffin-embedded human kidney tissue AAA230203 at dilution 1:100)
Related Product Information for anti-DNA2 antibody
Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair: recruited by BLM and mediates the cleavage of 5'-ssDNA, while the 3'-ssDNA cleavage is prevented by the presence of RPA. Also involved in DNA replication checkpoint independently of Okazaki fragments processing. Possesses different enzymatic activities, such as single-stranded DNA (ssDNA)-dependent ATPase, 5'-3' helicase and endonuclease activities. While the ATPase and endonuclease activities are well-defined and play a key role in Okazaki fragments processing and DSB repair, the 5'-3' DNA helicase activity is subject to debate. According to various reports, the helicase activity is weak and its function remains largely unclear. Helicase activity may promote the motion of DNA2 on the flap, helping the nuclease function.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
119,504 Da
NCBI Official Full Name
DNA replication ATP-dependent helicase/nuclease DNA2
NCBI Official Synonym Full Names
DNA replication helicase/nuclease 2
NCBI Official Symbol
DNA2
NCBI Official Synonym Symbols
DNA2L; hDNA2
NCBI Protein Information
DNA replication ATP-dependent helicase/nuclease DNA2
UniProt Protein Name
DNA replication ATP-dependent helicase/nuclease DNA2
UniProt Gene Name
DNA2
UniProt Synonym Gene Names
DNA2L; KIAA0083; hDNA2
UniProt Entry Name
DNA2_HUMAN
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Product Notes
The DNA2 dna2 (Catalog #AAA230203) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The DNA2 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's DNA2 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), ELISA. Researchers should empirically determine the suitability of the DNA2 dna2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "DNA2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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