Rabbit DRAM Polyclonal Antibody | anti-DRAM antibody

DRAM Antibody

Cat. Num. AAA40034

• Gene Names: DRAM1; DRAM
• Reactivity: Human, Mouse, Rat
• Applications: Immunofluorescence, Immunohistochemistry, Western Blot, ELISA
• Purity: DRAM Antibody is affinity chromatography purified via peptide column.
• Synonyms: DRAM, Antibody; DRAM Antibody; DRAM; DNA damage-regulated autophagy modulator protein 1; Damage-regulated autophagy modulator; damage-regulated autophagy modulator; anti-DRAM antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: DRAM Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 238

• Applicable Applications for anti-DRAM antibody: IF (Immunofluorescence), IHC (Immunohistochemistry), WB (Western Blot), ELISA
• Conjugate: Unconjugated
• Immunogen: DRAM antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human DRAM.
• Buffer: DRAM Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: DRAM antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IF (Immunofluorescence)

(Immunofluorescence of DRAM in Human Liver cells with DRAM antibody at 20 μg/mL.)

IHC (Immunohistochemistry)

(Immunohistochemistry of DRAM in human liver tissue with DRAM antibody at 2.5 μg/mL.)

Related Product Information for anti-DRAM antibody

DRAM Antibody: Damage-regulated autophagy modulator (DRAM) is a p53 target gene encoding a lysosomal protein that induces autophagy, a process that degrades cytosolic proteins and organelles. It has been suggested that activation of DRAM by p53 is simultaneous to the activation by p53 of one or more proapoptotic genes such as PUMA, Bax, etc., and that the signaling pathways regulated by these genes promote a full cell death response. By itself, DRAM cannot induce apoptosis, but the fact that it is inactivated in certain cancers highlights the importance of DRAM and suggests that autophagy may play a more important role in cancer than initially suspected. At least two different isoforms of DRAM are known to exist.

NCBI and Uniprot Product Information

• NCBI GI #: 22450862
• NCBI GeneID: 55332
• UniProt Accession #: Q8N682; Q7L3E3; Q9NUN1; B7Z4T0
• Molecular Weight: 13,972 Da
• NCBI Official Full Name: Damage-regulated autophagy modulator
• NCBI Official Synonym Full Names: DNA-damage regulated autophagy modulator 1
• NCBI Official Symbol: DRAM1
• NCBI Official Synonym Symbols: DRAM
• NCBI Protein Information: DNA damage-regulated autophagy modulator protein 1
• UniProt Protein Name: DNA damage-regulated autophagy modulator protein 1
• UniProt Gene Name: DRAM1
• UniProt Synonym Gene Names: DRAM
• UniProt Entry Name: DRAM1_HUMAN