Rabbit DRAM Polyclonal Antibody | anti-DRAM antibody

DRAM Antibody (N-term)

Cat. Num. AAA291028

• Gene Names: DRAM1; DRAM
• Reactivity: Human; Predicted Reactivity: Mouse
• Applications: Immunohistochemistry, Western Blot
• Purity: Affinity Purified Rabbit Polyclonal Antibody (Pab)
• Synonyms: DRAM, Antibody; DRAM Antibody (N-term); DNA damage-regulated autophagy modulator protein 1; Damage-regulated autophagy modulator; DRAM1; DRAM; anti-DRAM antibody

• Host: Rabbit
• Reactivity: Human; Predicted Reactivity: Mouse
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: This DRAM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 27-56 amino acids from the N-terminal region of human DRAM.
• Purity/Purification: Affinity Purified Rabbit Polyclonal Antibody (Pab)
• Form/Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

• Applicable Applications for anti-DRAM antibody: IHC (Immunohistochemistry), WB (Western Blot)
• Antigen Region: 27-56
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 2 weeks. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

IHC (Immunohiostchemistry)

(Dilution: IHC-P 1:10~50Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with *DRAM antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.)

WB (Western Blot)

(Dilution: WB 1:1000Western blot analysis of anti-DRAM Antibody (N-term) (Cat.#AAA291028) in HepG2 cell line lysates (35ug/lane). DRAM (arrow) was detected using the purified Pab.)

Related Product Information for anti-DRAM antibody

This gene is regulated as part of the p53 tumor suppressor pathway. The gene encodes a lysosomal membrane protein that is required for the induction of autophagy by the pathway. Decreased transcriptional expression of this gene is associated with various tumors. This gene has a pseudogene on chromosome 4.

Product Categories/Family for anti-DRAM antibody

Primary Antibodies; Cancer; Cardiovascular; Cell Biology; Metabolism

References

Kerley-Hamilton, J.S., Biochim. Biophys. Acta 1769 (4), 209-219 (2007) Crighton, D., Autophagy 3 (1), 72-74 (2007) Crighton, D., Cell 126 (1), 121-134 (2006) Green, D.R., Cell 126 (1), 30-32 (2006)

NCBI and Uniprot Product Information

• NCBI GI #: 110825978
• NCBI GeneID: 55332
• NCBI Accession #: NP_060840.2
• NCBI GenBank Nucleotide #: NM_018370.2
• UniProt Accession #: Q8N682; Q9DC58
• Molecular Weight: 13,972 Da
• NCBI Official Full Name: DNA damage-regulated autophagy modulator protein 1
• NCBI Official Synonym Full Names: DNA-damage regulated autophagy modulator 1
• NCBI Official Symbol: DRAM1
• NCBI Official Synonym Symbols: DRAM
• NCBI Protein Information: DNA damage-regulated autophagy modulator protein 1
• UniProt Protein Name: DNA damage-regulated autophagy modulator protein 1
• UniProt Gene Name: DRAM1
• UniProt Synonym Gene Names: DRAM
• UniProt Entry Name: DRAM1_HUMAN