WB (Western Blot)
(The anti-DUSP6 Pab is used in Western blot to detect DUSP6 in HeLa cell lysate.)
Rabbit DUSP6 Polyclonal Antibody | anti-DUSP6 antibody
DUSP6 Antibody (Center)
Gene Names
DUSP6; HH19; MKP3; PYST1
Reactivity
Human (Predicted Reactivity: Bovine)
Applications
Western Blot, ELISA, Immunofluorescence
Purity
Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
DUSP6, Antibody; DUSP6 Antibody (Center); Dual specificity protein phosphatase 6; Dual specificity protein phosphatase PYST1; Mitogen-activated protein kinase phosphatase 3; MAP kinase phosphatase 3; MKP-3; DUSP6; MKP3; PYST1; anti-DUSP6 antibody
Host
Rabbit
Reactivity
Human (Predicted Reactivity: Bovine)
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This DUSP6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 58-89 amino acids from the Central region of human DUSP6.
Purity/Purification
Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Concentration
Vial Concentration: 2 (varies by lot)
Sequence Positions
58-89
Sequence Length
235
Applicable Applications for anti-DUSP6 antibody
WB (Western Blot), ELISA, IF (Immunofluorescence)
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
WB (Western Blot)
(The anti-DUSP6 Pab is used in Western blot to detect DUSP6 in HeLa cell lysate.)
WB (Western Blot)
(The anti-DUSP6 Pab is used in Western blot to detect DUSP6 in HeLa cell lysate.)
IF (Immunofluorescence)
(Confocal immunofluorescent analysis of DUSP6 Antibody (Center) with Hela cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).)
IF (Immunofluorescence)
(Confocal immunofluorescent analysis of DUSP6 Antibody (Center) with Hela cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).)
Related Product Information for anti-DUSP6 antibody
DUSP6 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP)kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated
with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Two
transcript variants encoding different isoforms have been found for the DUSP6 gene.
with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Two
transcript variants encoding different isoforms have been found for the DUSP6 gene.
Product Categories/Family for anti-DUSP6 antibody
References
Mod. Pathol. 18 (8), 1034-1042 (2005)
J. Hum. Genet. 50 (4), 159-167 (2005)
J. Biol. Chem. 279 (40), 41882-41891 (2004)
Biochemistry 42 (51), 15197-15207 (2003)
J. Biol. Chem. 271 (8), 4319-4326 (1996)
J. Hum. Genet. 50 (4), 159-167 (2005)
J. Biol. Chem. 279 (40), 41882-41891 (2004)
Biochemistry 42 (51), 15197-15207 (2003)
J. Biol. Chem. 271 (8), 4319-4326 (1996)
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
42320
NCBI Official Full Name
dual specificity protein phosphatase 6 isoform a
NCBI Official Synonym Full Names
dual specificity phosphatase 6
NCBI Official Symbol
DUSP6
NCBI Official Synonym Symbols
HH19; MKP3; PYST1
NCBI Protein Information
dual specificity protein phosphatase 6
UniProt Protein Name
Dual specificity protein phosphatase 6
UniProt Gene Name
DUSP6
UniProt Synonym Gene Names
MKP3; PYST1; MAP kinase phosphatase 3; MKP-3
UniProt Entry Name
DUS6_HUMAN
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Product Notes
The DUSP6 dusp6 (Catalog #AAA290251) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 58-89. The DUSP6 Antibody (Center) reacts with Human (Predicted Reactivity: Bovine) and may cross-react with other species as described in the data sheet. AAA Biotech's DUSP6 can be used in a range of immunoassay formats including, but not limited to, WB (Western Blot), ELISA, IF (Immunofluorescence). Researchers should empirically determine the suitability of the DUSP6 dusp6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "DUSP6, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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